Phase I clinical study of oral olaparib in pediatric patients with refractory solid tumors: study protocol

BACKGROUND: There is no established standard chemotherapy for recurrent pediatric solid tumors such as neuroblastoma and sarcoma. Since some of these tumor cells show dysfunctions in homologous recombination repair, the goal is to conduct a phase I study of olaparib, a poly(ADP-ribose) polymerase in...

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Detalles Bibliográficos
Autores principales: Takagi, Masatoshi, Ogawa, Chitose, Aoki-Nogami, Yuki, Iehara, Tomoko, Ishibashi, Eri, Imai, Minoru, Kihara, Tetsuro, Nobori, Kiyoshi, Hasebe, Kazuhisa, Mizutani, Shuki, Kimura, Toshimi, Nagata, Masashi, Yasuhara, Masato, Yoshimura, Kenichi, Yorozu, Pariko, Hosoi, Hajime, Koike, Ryuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347807/
https://www.ncbi.nlm.nih.gov/pubmed/30684955
http://dx.doi.org/10.1186/s12887-019-1409-7

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