Molecular and epigenetic profiles of BRCA1-like hormone-receptor-positive breast tumors identified with development and application of a copy-number-based classifier

BACKGROUND: BRCA1-mutated cancers exhibit deficient homologous recombination (HR) DNA repair, resulting in extensive copy number alterations and genome instability. HR deficiency can also arise in tumors without a BRCA1 mutation. Compared with other breast tumors, HR-deficient, BRCA1-like tumors exh...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Youdinghuan, Wang, Yue, Salas, Lucas A., Miller, Todd W., Mark, Kenneth, Marotti, Jonathan D., Kettenbach, Arminja N., Cheng, Chao, Christensen, Brock C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347811/
https://www.ncbi.nlm.nih.gov/pubmed/30683142
http://dx.doi.org/10.1186/s13058-018-1090-z

Ejemplares similares

Ejemplares similares