High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascites

OBJECTIVES: The purpose of this study was to evaluate the effect of gabapentin on Ehrlich tumor growth in Swiss mice, a highly aggressive and inflammatory tumor model. Mice were grouped into sets of 5 animals and treated from days 2 to 8 with gabapentin 30 mg/kg body weight (G30) or 100 mg/kg body w...

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Detalles Bibliográficos
Autores principales: da Cunha Leal, Plinio, Rey Moura, Ed Carlos, Jorge Dino Cossetti, Rachel, Ramos do Nascimento, Johnny, Portela Bogéa Serra, Izabel Cristina, de Paulo Ribeiro, Bruno, Álvares Marques Vale, Andre, Silva de Azevedo dos Santos, Ana Paula, Fernandes do Nascimento, Flavia Raquel, Kimiko Sakata, Rioko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347815/
https://www.ncbi.nlm.nih.gov/pubmed/30683148
http://dx.doi.org/10.1186/s13104-019-4103-9

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