Targeting the tumor stroma with an oncolytic adenovirus secreting a fibroblast activation protein-targeted bispecific T-cell engager

BACKGROUND: Oncolytic virus (OV)-based therapies have an emerging role in the treatment of solid tumors, involving both direct cell lysis and immunogenic cell death. Nonetheless, tumor-associated stroma limits the efficacy of oncolytic viruses by forming a barrier that blocks efficient viral penetra...

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Detalles Bibliográficos
Autores principales: de Sostoa, Jana, Fajardo, Carlos Alberto, Moreno, Rafael, Ramos, Maria D., Farrera-Sal, Martí, Alemany, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347837/
https://www.ncbi.nlm.nih.gov/pubmed/30683154
http://dx.doi.org/10.1186/s40425-019-0505-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347837/
https://www.ncbi.nlm.nih.gov/pubmed/30683154
http://dx.doi.org/10.1186/s40425-019-0505-4

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