Metabolic analysis of acute appendicitis by using system biology approach

AIM: Introducing possible suitable compound as diagnostic agent in appendicitis is aim of this investigation. BACKGROUND: Appendicitis diagnosis is a difficult step in treatment of disease due to complex abdominal pain signal which may be refer to the non-appendicitis pain. METHODS: Gene expression profiles of children with non-preforated appendicitis in comparison with the samples with non- appendicitis abdominal pain are analysis via protein – protein interaction (PPI) and the critical compounds are introduced by STITCH. RESULTS: Ten compounds including including MgATP, glycerol, MgADP, calcium ions, chloride, magnesium, phosphate, sulphate, acetate, and sodium are introduced as possible biomarker panel to differentiate appendicitis from the other abdominal pains. CONCLUSION: A laboratory method such as flame photometry based on metal detection for diagnosis of appendicitis is possible, however more investigations are required.