Tissue-Specific Chk1 Activation Determines Apoptosis by Regulating the Balance of p53 and p21

The DNA damage response (DDR) protects cells against genomic instability. Surprisingly, little is known about the differences in DDR across tissues, which may affect cancer evolutionary trajectories and chemotherapy response. Using mathematical modeling and quantitative experiments, we found that th...

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Detalles Bibliográficos
Autores principales: van Jaarsveld, Marijn T.M., Deng, Difan, Wiemer, Erik A.C., Zi, Zhike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348202/
https://www.ncbi.nlm.nih.gov/pubmed/30665195
http://dx.doi.org/10.1016/j.isci.2019.01.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348202/
https://www.ncbi.nlm.nih.gov/pubmed/30665195
http://dx.doi.org/10.1016/j.isci.2019.01.001

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