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Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy
Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve T cell activation and effector differentiation. They are, likewise, involved in the induction and maintenance of immune tolerance in homeostatic conditions. Their phenotypic and functional heterogeneity poi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348254/ https://www.ncbi.nlm.nih.gov/pubmed/30719026 http://dx.doi.org/10.3389/fimmu.2018.03176 |
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author | Patente, Thiago A. Pinho, Mariana P. Oliveira, Aline A. Evangelista, Gabriela C. M. Bergami-Santos, Patrícia C. Barbuto, José A. M. |
author_facet | Patente, Thiago A. Pinho, Mariana P. Oliveira, Aline A. Evangelista, Gabriela C. M. Bergami-Santos, Patrícia C. Barbuto, José A. M. |
author_sort | Patente, Thiago A. |
collection | PubMed |
description | Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve T cell activation and effector differentiation. They are, likewise, involved in the induction and maintenance of immune tolerance in homeostatic conditions. Their phenotypic and functional heterogeneity points to their great plasticity and ability to modulate, according to their microenvironment, the acquired immune response and, at the same time, makes their precise classification complex and frequently subject to reviews and improvement. This review will present general aspects of the DC physiology and classification and will address their potential and actual uses in the management of human disease, more specifically cancer, as therapeutic and monitoring tools. New combination treatments with the participation of DC will be also discussed. |
format | Online Article Text |
id | pubmed-6348254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63482542019-02-04 Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy Patente, Thiago A. Pinho, Mariana P. Oliveira, Aline A. Evangelista, Gabriela C. M. Bergami-Santos, Patrícia C. Barbuto, José A. M. Front Immunol Immunology Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve T cell activation and effector differentiation. They are, likewise, involved in the induction and maintenance of immune tolerance in homeostatic conditions. Their phenotypic and functional heterogeneity points to their great plasticity and ability to modulate, according to their microenvironment, the acquired immune response and, at the same time, makes their precise classification complex and frequently subject to reviews and improvement. This review will present general aspects of the DC physiology and classification and will address their potential and actual uses in the management of human disease, more specifically cancer, as therapeutic and monitoring tools. New combination treatments with the participation of DC will be also discussed. Frontiers Media S.A. 2019-01-21 /pmc/articles/PMC6348254/ /pubmed/30719026 http://dx.doi.org/10.3389/fimmu.2018.03176 Text en Copyright © 2019 Patente, Pinho, Oliveira, Evangelista, Bergami-Santos and Barbuto. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Patente, Thiago A. Pinho, Mariana P. Oliveira, Aline A. Evangelista, Gabriela C. M. Bergami-Santos, Patrícia C. Barbuto, José A. M. Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy |
title | Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy |
title_full | Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy |
title_fullStr | Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy |
title_full_unstemmed | Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy |
title_short | Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy |
title_sort | human dendritic cells: their heterogeneity and clinical application potential in cancer immunotherapy |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348254/ https://www.ncbi.nlm.nih.gov/pubmed/30719026 http://dx.doi.org/10.3389/fimmu.2018.03176 |
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