Cargando…
Therapeutic Potential of Natural Killer Cells in Gastric Cancer
Gastric cancer (GC) is one of the most common cancers, with a high incidence of cancer death. Despite various therapeutic approaches, the cures and prognosis of advanced GC remain poor. Natural killer (NK) cells, which are known as important lymphocytes in innate immunity, play vital roles in suppre...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348255/ https://www.ncbi.nlm.nih.gov/pubmed/30719024 http://dx.doi.org/10.3389/fimmu.2018.03095 |
_version_ | 1783390064487694336 |
---|---|
author | Du, Yu Wei, Yongchang |
author_facet | Du, Yu Wei, Yongchang |
author_sort | Du, Yu |
collection | PubMed |
description | Gastric cancer (GC) is one of the most common cancers, with a high incidence of cancer death. Despite various therapeutic approaches, the cures and prognosis of advanced GC remain poor. Natural killer (NK) cells, which are known as important lymphocytes in innate immunity, play vital roles in suppressing GC initiation, progression, and metastases. A wide range of clinical settings shows that increasing the number of NK cells or improving NK cell antitumor activity is promising in GC patients. NK cell adoptive therapy (especially expanded NK cells) is a safe and well-tolerated method, which can enhance NK cell cytotoxicity against GC. Meanwhile, cytokines, immunomodulatory drugs, immune checkpoint blockades, antibodies, vaccines, and gene therapy have been found to directly or indirectly activate NK cells to improve their killing activity toward GC. In this review, we summarize recent advancements in the relationship between NK cells and GC and point out all the innovative strategies that can enhance NK cells' function to inhibit the growth of GC. |
format | Online Article Text |
id | pubmed-6348255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63482552019-02-04 Therapeutic Potential of Natural Killer Cells in Gastric Cancer Du, Yu Wei, Yongchang Front Immunol Immunology Gastric cancer (GC) is one of the most common cancers, with a high incidence of cancer death. Despite various therapeutic approaches, the cures and prognosis of advanced GC remain poor. Natural killer (NK) cells, which are known as important lymphocytes in innate immunity, play vital roles in suppressing GC initiation, progression, and metastases. A wide range of clinical settings shows that increasing the number of NK cells or improving NK cell antitumor activity is promising in GC patients. NK cell adoptive therapy (especially expanded NK cells) is a safe and well-tolerated method, which can enhance NK cell cytotoxicity against GC. Meanwhile, cytokines, immunomodulatory drugs, immune checkpoint blockades, antibodies, vaccines, and gene therapy have been found to directly or indirectly activate NK cells to improve their killing activity toward GC. In this review, we summarize recent advancements in the relationship between NK cells and GC and point out all the innovative strategies that can enhance NK cells' function to inhibit the growth of GC. Frontiers Media S.A. 2019-01-21 /pmc/articles/PMC6348255/ /pubmed/30719024 http://dx.doi.org/10.3389/fimmu.2018.03095 Text en Copyright © 2019 Du and Wei. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Du, Yu Wei, Yongchang Therapeutic Potential of Natural Killer Cells in Gastric Cancer |
title | Therapeutic Potential of Natural Killer Cells in Gastric Cancer |
title_full | Therapeutic Potential of Natural Killer Cells in Gastric Cancer |
title_fullStr | Therapeutic Potential of Natural Killer Cells in Gastric Cancer |
title_full_unstemmed | Therapeutic Potential of Natural Killer Cells in Gastric Cancer |
title_short | Therapeutic Potential of Natural Killer Cells in Gastric Cancer |
title_sort | therapeutic potential of natural killer cells in gastric cancer |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348255/ https://www.ncbi.nlm.nih.gov/pubmed/30719024 http://dx.doi.org/10.3389/fimmu.2018.03095 |
work_keys_str_mv | AT duyu therapeuticpotentialofnaturalkillercellsingastriccancer AT weiyongchang therapeuticpotentialofnaturalkillercellsingastriccancer |