Brain Derived Neurotrophic Factor (BDNF) Delays Onset of Pathogenesis in Transgenic Mouse Model of Spinocerebellar Ataxia Type 1 (SCA1)

Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by an abnormal expansion of CAG repeats in the Ataxin-1 (ATXN1) gene and characterized by motor deficits and cerebellar neurodegeneration. Even though mutant ATXN1 is expressed from an early age, disease onset usually o...

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Detalles Bibliográficos
Autores principales: Mellesmoen, Aaron, Sheeler, Carrie, Ferro, Austin, Rainwater, Orion, Cvetanovic, Marija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348256/
https://www.ncbi.nlm.nih.gov/pubmed/30718999
http://dx.doi.org/10.3389/fncel.2018.00509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348256/
https://www.ncbi.nlm.nih.gov/pubmed/30718999
http://dx.doi.org/10.3389/fncel.2018.00509

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