Short, Tin‐Free Synthesis of All Three Inthomycins

The inthomycins are a family of structurally and biologically rich natural products isolated from Streptomyces species. Herein the implementation of a modular synthetic route is reported that has enabled the enantioselective synthesis of all three inthomycins. Key steps include Suzuki and Sonogashir...

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Detalles Bibliográficos
Autores principales: Kumar, Manjeet, Bromhead, Liam, Anderson, Zoe, Overy, Alistair, Burton, Jonathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348375/
https://www.ncbi.nlm.nih.gov/pubmed/30338587
http://dx.doi.org/10.1002/chem.201803794
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author Kumar, Manjeet
Bromhead, Liam
Anderson, Zoe
Overy, Alistair
Burton, Jonathan W.
author_facet Kumar, Manjeet
Bromhead, Liam
Anderson, Zoe
Overy, Alistair
Burton, Jonathan W.
author_sort Kumar, Manjeet
collection PubMed
description The inthomycins are a family of structurally and biologically rich natural products isolated from Streptomyces species. Herein the implementation of a modular synthetic route is reported that has enabled the enantioselective synthesis of all three inthomycins. Key steps include Suzuki and Sonogashira cross‐couplings and an enantioselective Kiyooka aldol reaction.
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spelling pubmed-63483752019-01-31 Short, Tin‐Free Synthesis of All Three Inthomycins Kumar, Manjeet Bromhead, Liam Anderson, Zoe Overy, Alistair Burton, Jonathan W. Chemistry Communications The inthomycins are a family of structurally and biologically rich natural products isolated from Streptomyces species. Herein the implementation of a modular synthetic route is reported that has enabled the enantioselective synthesis of all three inthomycins. Key steps include Suzuki and Sonogashira cross‐couplings and an enantioselective Kiyooka aldol reaction. John Wiley and Sons Inc. 2018-10-19 2018-11-13 /pmc/articles/PMC6348375/ /pubmed/30338587 http://dx.doi.org/10.1002/chem.201803794 Text en © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Kumar, Manjeet
Bromhead, Liam
Anderson, Zoe
Overy, Alistair
Burton, Jonathan W.
Short, Tin‐Free Synthesis of All Three Inthomycins
title Short, Tin‐Free Synthesis of All Three Inthomycins
title_full Short, Tin‐Free Synthesis of All Three Inthomycins
title_fullStr Short, Tin‐Free Synthesis of All Three Inthomycins
title_full_unstemmed Short, Tin‐Free Synthesis of All Three Inthomycins
title_short Short, Tin‐Free Synthesis of All Three Inthomycins
title_sort short, tin‐free synthesis of all three inthomycins
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348375/
https://www.ncbi.nlm.nih.gov/pubmed/30338587
http://dx.doi.org/10.1002/chem.201803794
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AT andersonzoe shorttinfreesynthesisofallthreeinthomycins
AT overyalistair shorttinfreesynthesisofallthreeinthomycins
AT burtonjonathanw shorttinfreesynthesisofallthreeinthomycins

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