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Fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, with an anti-tumor predictor of glycine

Fucoxanthin and its major metabolite, fucoxanthinol, have potent anti-cancer properties in carcinogenic model mice and against cancer cells. Evidence has accumulated regarding the diagnostic potential of biological metabolites as invasive and non-invasive obtainable approaches. We recently demonstra...

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Autores principales: Terasaki, Masaru, Matsumoto, Naoya, Hashimoto, Ryuichi, Endo, Tetsuya, Maeda, Hayato, Hamada, Junichi, Osada, Kazumi, Miyashita, Kazuo, Mutoh, Michihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348407/
https://www.ncbi.nlm.nih.gov/pubmed/30705512
http://dx.doi.org/10.3164/jcbn.18-45
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author Terasaki, Masaru
Matsumoto, Naoya
Hashimoto, Ryuichi
Endo, Tetsuya
Maeda, Hayato
Hamada, Junichi
Osada, Kazumi
Miyashita, Kazuo
Mutoh, Michihiro
author_facet Terasaki, Masaru
Matsumoto, Naoya
Hashimoto, Ryuichi
Endo, Tetsuya
Maeda, Hayato
Hamada, Junichi
Osada, Kazumi
Miyashita, Kazuo
Mutoh, Michihiro
author_sort Terasaki, Masaru
collection PubMed
description Fucoxanthin and its major metabolite, fucoxanthinol, have potent anti-cancer properties in carcinogenic model mice and against cancer cells. Evidence has accumulated regarding the diagnostic potential of biological metabolites as invasive and non-invasive obtainable approaches. We recently demonstrated that glycine was an effective predictor of the suppression of sphere formation and epithelial mesenchymal transition by fucoxanthinol in human colorectal cancer stem-like spheroids (colonospheres) under normoxia and hypoxia. In the present study, we investigated the suppressive effect of fucoxanthin on tumorigenesis derived from colonospheres in xenograft mice, and the alteration on the metabolite profiles of mouse tumors by fucoxanthin was evaluated. Fucoxanthin administration at 2.5 mg/kg body weight (p.o.) for 4 weeks significantly inhibited the incidence of tumors by inoculation of colonospheres suspension in BALB/c nu/nu mice compared with control mice, but not tumor sizes. In addition, fucoxanthin down-regulated tumor Cyclin D1 expression by 0.7-fold of that observed in the tumors of the control mice. Moreover, the tumor glycine level in the xenograft mice was decreased by fucoxanthin administration to 0.5-fold. These results imply the possibility of tumor metabolites as a prediction marker of tumorigenicity derived from colorectal cancer stem cells in mice.
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spelling pubmed-63484072019-01-31 Fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, with an anti-tumor predictor of glycine Terasaki, Masaru Matsumoto, Naoya Hashimoto, Ryuichi Endo, Tetsuya Maeda, Hayato Hamada, Junichi Osada, Kazumi Miyashita, Kazuo Mutoh, Michihiro J Clin Biochem Nutr Original Article Fucoxanthin and its major metabolite, fucoxanthinol, have potent anti-cancer properties in carcinogenic model mice and against cancer cells. Evidence has accumulated regarding the diagnostic potential of biological metabolites as invasive and non-invasive obtainable approaches. We recently demonstrated that glycine was an effective predictor of the suppression of sphere formation and epithelial mesenchymal transition by fucoxanthinol in human colorectal cancer stem-like spheroids (colonospheres) under normoxia and hypoxia. In the present study, we investigated the suppressive effect of fucoxanthin on tumorigenesis derived from colonospheres in xenograft mice, and the alteration on the metabolite profiles of mouse tumors by fucoxanthin was evaluated. Fucoxanthin administration at 2.5 mg/kg body weight (p.o.) for 4 weeks significantly inhibited the incidence of tumors by inoculation of colonospheres suspension in BALB/c nu/nu mice compared with control mice, but not tumor sizes. In addition, fucoxanthin down-regulated tumor Cyclin D1 expression by 0.7-fold of that observed in the tumors of the control mice. Moreover, the tumor glycine level in the xenograft mice was decreased by fucoxanthin administration to 0.5-fold. These results imply the possibility of tumor metabolites as a prediction marker of tumorigenicity derived from colorectal cancer stem cells in mice. the Society for Free Radical Research Japan 2019-01 2018-07-25 /pmc/articles/PMC6348407/ /pubmed/30705512 http://dx.doi.org/10.3164/jcbn.18-45 Text en Copyright © 2019 JCBN http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Terasaki, Masaru
Matsumoto, Naoya
Hashimoto, Ryuichi
Endo, Tetsuya
Maeda, Hayato
Hamada, Junichi
Osada, Kazumi
Miyashita, Kazuo
Mutoh, Michihiro
Fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, with an anti-tumor predictor of glycine
title Fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, with an anti-tumor predictor of glycine
title_full Fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, with an anti-tumor predictor of glycine
title_fullStr Fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, with an anti-tumor predictor of glycine
title_full_unstemmed Fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, with an anti-tumor predictor of glycine
title_short Fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, with an anti-tumor predictor of glycine
title_sort fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, with an anti-tumor predictor of glycine
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348407/
https://www.ncbi.nlm.nih.gov/pubmed/30705512
http://dx.doi.org/10.3164/jcbn.18-45
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