Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function

Stimulator of interferon genes (STING) plays a key role in detecting cytosolic DNA and induces type I interferon (IFN-I) responses for host defense against pathogens. Although T cells highly express STING, its physiological role remains unknown. Here, we show that costimulation of T cells with the S...

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Detalles Bibliográficos
Autores principales: Imanishi, Takayuki, Unno, Midori, Kobayashi, Wakana, Yoneda, Natsumi, Matsuda, Satoshi, Ikeda, Kazutaka, Hoshii, Takayuki, Hirao, Atsushi, Miyake, Kensuke, Barber, Glen N, Arita, Makoto, Ishii, Ken J, Akira, Shizuo, Saito, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348487/
https://www.ncbi.nlm.nih.gov/pubmed/30683688
http://dx.doi.org/10.26508/lsa.201800282

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