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Inhibition by O-desmethyltramadol of glutamatergic excitatory transmission in adult rat spinal substantia gelatinosa neurons

To reveal cellular mechanisms for antinociception produced by clinically used tramadol, we investigated the effect of its metabolite O-desmethyltramadol (M1) on glutamatergic excitatory transmission in spinal dorsal horn lamina II (substantia gelatinosa; SG) neurons. The whole-cell patch-clamp techn...

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Detalles Bibliográficos
Autores principales:	Koga, Akiko, Fujita, Tsugumi, Piao, Lian-Hua, Nakatsuka, Terumasa, Kumamoto, Eiichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348506/ https://www.ncbi.nlm.nih.gov/pubmed/30799694 http://dx.doi.org/10.1177/1744806918824243

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