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Time-to-recovery from severe acute malnutrition in children 6–59 months of age enrolled in the outpatient treatment program in Shebedino, Southern Ethiopia: a prospective cohort study

BACKGROUND: In Ethiopia uncomplicated severe acute malnutrition (SAM) is managed at health posts level through the outpatient therapeutic program (OTP). Yet, evidence on the treatment success rate of the program is scarce. This study determines the treatment outcomes and predictors of time-to-recove...

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Autores principales: Teshome, Genene, Bosha, Tafese, Gebremedhin, Samson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348627/
https://www.ncbi.nlm.nih.gov/pubmed/30691437
http://dx.doi.org/10.1186/s12887-019-1407-9
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author Teshome, Genene
Bosha, Tafese
Gebremedhin, Samson
author_facet Teshome, Genene
Bosha, Tafese
Gebremedhin, Samson
author_sort Teshome, Genene
collection PubMed
description BACKGROUND: In Ethiopia uncomplicated severe acute malnutrition (SAM) is managed at health posts level through the outpatient therapeutic program (OTP). Yet, evidence on the treatment success rate of the program is scarce. This study determines the treatment outcomes and predictors of time-to-recovery among children 6–59 months of age with SAM managed at the health posts level in Shebedino district, Southern Ethiopia. METHODS: This was a prospective cohort study that enrolled 216 children with SAM identified through a campaign conducted in May 2015 and treated over eight weeks at 25 health posts of the district. The average time-to-recovery was estimated using Kaplan-Meier survival curve and the independent predictors of the recovery were determined using multivariable Cox-proportional hazard model. The outputs of the analyses are presented via adjusted hazard ratio with 95% confidence intervals (AHR, CI). RESULTS: At the end of the eight weeks of treatment 79.6% (95% CI: 74.2–85.0%) of cases recovered from SAM with a weight gain rate of 5.4 g/kg/day. The median time-to-recover was 36 days. The analysis indicated, maternal illiteracy (0.54, 0.38–0.78), severe household food insecurity (0.47, 0.28–0.79), walking for more than 1 h to receive the treatment (0.69, 0.50–0.96), diarrhoea co-morbidity (0.63, 0.42–0.91) and practicing sharing of ready to use therapeutic food (RUTF) (0.53, 0.32–0.88) were associated with slower propensity of recovery from SAM. Children who were enrolled with marasmus diagnosis showed lower recovery than children with kwashiorkor (0.30, 0.18–0.51). CONCLUSION: The median time-to-recover was 36 days. Discouraging sharing of RUTF, appropriate management of diarrhoea in SAM cases and improving access to OTP sites can help to improve the treatment outcome for SAM. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12887-019-1407-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-63486272019-01-31 Time-to-recovery from severe acute malnutrition in children 6–59 months of age enrolled in the outpatient treatment program in Shebedino, Southern Ethiopia: a prospective cohort study Teshome, Genene Bosha, Tafese Gebremedhin, Samson BMC Pediatr Research Article BACKGROUND: In Ethiopia uncomplicated severe acute malnutrition (SAM) is managed at health posts level through the outpatient therapeutic program (OTP). Yet, evidence on the treatment success rate of the program is scarce. This study determines the treatment outcomes and predictors of time-to-recovery among children 6–59 months of age with SAM managed at the health posts level in Shebedino district, Southern Ethiopia. METHODS: This was a prospective cohort study that enrolled 216 children with SAM identified through a campaign conducted in May 2015 and treated over eight weeks at 25 health posts of the district. The average time-to-recovery was estimated using Kaplan-Meier survival curve and the independent predictors of the recovery were determined using multivariable Cox-proportional hazard model. The outputs of the analyses are presented via adjusted hazard ratio with 95% confidence intervals (AHR, CI). RESULTS: At the end of the eight weeks of treatment 79.6% (95% CI: 74.2–85.0%) of cases recovered from SAM with a weight gain rate of 5.4 g/kg/day. The median time-to-recover was 36 days. The analysis indicated, maternal illiteracy (0.54, 0.38–0.78), severe household food insecurity (0.47, 0.28–0.79), walking for more than 1 h to receive the treatment (0.69, 0.50–0.96), diarrhoea co-morbidity (0.63, 0.42–0.91) and practicing sharing of ready to use therapeutic food (RUTF) (0.53, 0.32–0.88) were associated with slower propensity of recovery from SAM. Children who were enrolled with marasmus diagnosis showed lower recovery than children with kwashiorkor (0.30, 0.18–0.51). CONCLUSION: The median time-to-recover was 36 days. Discouraging sharing of RUTF, appropriate management of diarrhoea in SAM cases and improving access to OTP sites can help to improve the treatment outcome for SAM. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12887-019-1407-9) contains supplementary material, which is available to authorized users. BioMed Central 2019-01-28 /pmc/articles/PMC6348627/ /pubmed/30691437 http://dx.doi.org/10.1186/s12887-019-1407-9 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Teshome, Genene
Bosha, Tafese
Gebremedhin, Samson
Time-to-recovery from severe acute malnutrition in children 6–59 months of age enrolled in the outpatient treatment program in Shebedino, Southern Ethiopia: a prospective cohort study
title Time-to-recovery from severe acute malnutrition in children 6–59 months of age enrolled in the outpatient treatment program in Shebedino, Southern Ethiopia: a prospective cohort study
title_full Time-to-recovery from severe acute malnutrition in children 6–59 months of age enrolled in the outpatient treatment program in Shebedino, Southern Ethiopia: a prospective cohort study
title_fullStr Time-to-recovery from severe acute malnutrition in children 6–59 months of age enrolled in the outpatient treatment program in Shebedino, Southern Ethiopia: a prospective cohort study
title_full_unstemmed Time-to-recovery from severe acute malnutrition in children 6–59 months of age enrolled in the outpatient treatment program in Shebedino, Southern Ethiopia: a prospective cohort study
title_short Time-to-recovery from severe acute malnutrition in children 6–59 months of age enrolled in the outpatient treatment program in Shebedino, Southern Ethiopia: a prospective cohort study
title_sort time-to-recovery from severe acute malnutrition in children 6–59 months of age enrolled in the outpatient treatment program in shebedino, southern ethiopia: a prospective cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348627/
https://www.ncbi.nlm.nih.gov/pubmed/30691437
http://dx.doi.org/10.1186/s12887-019-1407-9
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