Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy

Sporadic cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular amyloid-β (Aβ) deposition, which leads to lobar hemorrhage and dementia. Biological molecules affecting the development of CAA have not been fully characterized. In this study, we performed proteome analysis of biopsied l...

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Detalles Bibliográficos
Autores principales: Endo, Yoshinori, Hasegawa, Kazuhiro, Nomura, Ryo, Arishima, Hidetaka, Kikuta, Ken-ichiro, Yamashita, Taro, Inoue, Yasuteru, Ueda, Mitsuharu, Ando, Yukio, Wilson, Mark R., Hamano, Tadanori, Nakamoto, Yasunari, Naiki, Hironobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348632/
https://www.ncbi.nlm.nih.gov/pubmed/30691533
http://dx.doi.org/10.1186/s40478-019-0662-1

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