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Genetic risk variants for brain disorders are enriched in cortical H3K27ac domains

Most variants associated with complex phenotypes in genome-wide association studies (GWAS) do not directly index coding changes affecting protein structure. Instead they are hypothesized to influence gene regulation, with common variants associated with disease being enriched in regulatory domains i...

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Detalles Bibliográficos
Autores principales:	Hannon, Eilis, Marzi, Sarah J., Schalkwyk, Leonard S., Mill, Jonathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348673/ https://www.ncbi.nlm.nih.gov/pubmed/30691483 http://dx.doi.org/10.1186/s13041-019-0429-4

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