S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension

Krüppel-like factor 4 (KLF4) is a transcription factor with conserved zinc finger domains. As an essential regulator of vascular homeostasis, KLF4 exerts a protective effect in endothelial cells (ECs), including regulating vasodilation, inflammation, coagulation and oxidative stress. However, the un...

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Detalles Bibliográficos
Autores principales: Ban, Yiqian, Liu, Yahan, Li, Yazi, Zhang, Yuying, Xiao, Lei, Gu, Yue, Chen, Shaoliang, Zhao, Beilei, Chen, Chang, Wang, Nanping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348764/
https://www.ncbi.nlm.nih.gov/pubmed/30660098
http://dx.doi.org/10.1016/j.redox.2019.101099

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