miR-124, a potential therapeutic target in colorectal cancer

Recently, miR-124 has been regarded as a critical modulator of colorectal cancer. We here summarize the studies on the role and mechanism of miR-124 in colorectal cancer. They indicate that miR-124 is methylated during carcinogenesis and functions as a tumor-suppressor in colorectal cancer. miR-124...

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Detalles Bibliográficos
Autores principales: Qin, Zhen, Liu, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348970/
https://www.ncbi.nlm.nih.gov/pubmed/30774362
http://dx.doi.org/10.2147/OTT.S179501
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author Qin, Zhen
Liu, Xia
author_facet Qin, Zhen
Liu, Xia
author_sort Qin, Zhen
collection PubMed
description Recently, miR-124 has been regarded as a critical modulator of colorectal cancer. We here summarize the studies on the role and mechanism of miR-124 in colorectal cancer. They indicate that miR-124 is methylated during carcinogenesis and functions as a tumor-suppressor in colorectal cancer. miR-124 might serve as a potential diagnostic biomarker and therapeutic target in colorectal cancer in the foreseeable future.
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spelling pubmed-63489702019-02-15 miR-124, a potential therapeutic target in colorectal cancer Qin, Zhen Liu, Xia Onco Targets Ther Perspectives Recently, miR-124 has been regarded as a critical modulator of colorectal cancer. We here summarize the studies on the role and mechanism of miR-124 in colorectal cancer. They indicate that miR-124 is methylated during carcinogenesis and functions as a tumor-suppressor in colorectal cancer. miR-124 might serve as a potential diagnostic biomarker and therapeutic target in colorectal cancer in the foreseeable future. Dove Medical Press 2019-01-22 /pmc/articles/PMC6348970/ /pubmed/30774362 http://dx.doi.org/10.2147/OTT.S179501 Text en © 2019 Qin and Liu. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Perspectives
Qin, Zhen
Liu, Xia
miR-124, a potential therapeutic target in colorectal cancer
title miR-124, a potential therapeutic target in colorectal cancer
title_full miR-124, a potential therapeutic target in colorectal cancer
title_fullStr miR-124, a potential therapeutic target in colorectal cancer
title_full_unstemmed miR-124, a potential therapeutic target in colorectal cancer
title_short miR-124, a potential therapeutic target in colorectal cancer
title_sort mir-124, a potential therapeutic target in colorectal cancer
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348970/
https://www.ncbi.nlm.nih.gov/pubmed/30774362
http://dx.doi.org/10.2147/OTT.S179501
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