A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates

Antibody–drug conjugates (ADCs) are a class of targeted therapeutics that utilize the specificity of antibodies to selectively deliver highly potent cytotoxins to target cells. Although recent years have witnessed significant interest in ADCs, problems remain with the standard linkage chemistries us...

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Detalles Bibliográficos
Autores principales: Walsh, Stephen J., Omarjee, Soleilmane, Galloway, Warren R. J. D., Kwan, Terence T.-L., Sore, Hannah F., Parker, Jeremy S., Hyvönen, Marko, Carroll, Jason S., Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349026/
https://www.ncbi.nlm.nih.gov/pubmed/30774870
http://dx.doi.org/10.1039/c8sc04645j

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