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pH as a potential therapeutic target to improve temozolomide antitumor efficacy : A mechanistic modeling study

Despite intensive treatments including temozolomide (TMZ) administration, glioblastoma patient prognosis remains dismal and innovative therapeutic strategies are urgently needed. A systems pharmacology approach was undertaken to investigate TMZ pharmacokinetics‐pharmacodynamics (PK‐PD) incorporating...

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Detalles Bibliográficos
Autores principales:	Stéphanou, Angélique, Ballesta, Annabelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349072/ https://www.ncbi.nlm.nih.gov/pubmed/30705757 http://dx.doi.org/10.1002/prp2.454

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