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CD147 promotes progression of head and neck squamous cell carcinoma via NF‐kappa B signaling

CD147/basigin (BSG) is highly upregulated in many types of cancer, our previous study has found that CD147/BSG is highly expressed in head and neck squamous cell carcinoma (HNSCC) stem cells, but its role in HNSCC and the underlying mechanism is still unknown. In this study, we investigated the role...

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Autores principales: Yu, Binbin, Zhang, Yan, Wu, Kailiu, Wang, Lizhen, Jiang, Yingying, Chen, Wantao, Yan, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349162/
https://www.ncbi.nlm.nih.gov/pubmed/30421493
http://dx.doi.org/10.1111/jcmm.13996
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author Yu, Binbin
Zhang, Yan
Wu, Kailiu
Wang, Lizhen
Jiang, Yingying
Chen, Wantao
Yan, Ming
author_facet Yu, Binbin
Zhang, Yan
Wu, Kailiu
Wang, Lizhen
Jiang, Yingying
Chen, Wantao
Yan, Ming
author_sort Yu, Binbin
collection PubMed
description CD147/basigin (BSG) is highly upregulated in many types of cancer, our previous study has found that CD147/BSG is highly expressed in head and neck squamous cell carcinoma (HNSCC) stem cells, but its role in HNSCC and the underlying mechanism is still unknown. In this study, we investigated the role of CD147 in the progression of HNSCC. Real‐time PCR, western blot and immunohistochemistry were used to detect the expression of CD147 in total 189 HNSCC tissues in compared with normal tissues. In addition, we used proliferation, colony formation, cell cycle and apoptosis, migration and invasion as well as wound‐healing assay to determine the biological roles of CD147 in HNSCC. Then, a xenograft model was performed to evaluate tumor‐promoting and metastasis‐promoting role of CD147 in HNSCC. The results showed that upregulated CD147 expression was associated with aggressive clinicopathologic features in HNSCC. In addition, CD147 promoted proliferation, migration and reduced the apoptosis phenotype of HNSCC cells in vitro as well as tumor initiation and progression in vivo. Furthermore, we demonstrated that CD147 promoted HNSCC progression through nuclear factor kappa B signaling. Therefore, we concluded that CD147 promoted tumor progression in HNSCC and might be a potential prognostic and treatment biomarker for HNSCC.
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spelling pubmed-63491622019-02-01 CD147 promotes progression of head and neck squamous cell carcinoma via NF‐kappa B signaling Yu, Binbin Zhang, Yan Wu, Kailiu Wang, Lizhen Jiang, Yingying Chen, Wantao Yan, Ming J Cell Mol Med Original Articles CD147/basigin (BSG) is highly upregulated in many types of cancer, our previous study has found that CD147/BSG is highly expressed in head and neck squamous cell carcinoma (HNSCC) stem cells, but its role in HNSCC and the underlying mechanism is still unknown. In this study, we investigated the role of CD147 in the progression of HNSCC. Real‐time PCR, western blot and immunohistochemistry were used to detect the expression of CD147 in total 189 HNSCC tissues in compared with normal tissues. In addition, we used proliferation, colony formation, cell cycle and apoptosis, migration and invasion as well as wound‐healing assay to determine the biological roles of CD147 in HNSCC. Then, a xenograft model was performed to evaluate tumor‐promoting and metastasis‐promoting role of CD147 in HNSCC. The results showed that upregulated CD147 expression was associated with aggressive clinicopathologic features in HNSCC. In addition, CD147 promoted proliferation, migration and reduced the apoptosis phenotype of HNSCC cells in vitro as well as tumor initiation and progression in vivo. Furthermore, we demonstrated that CD147 promoted HNSCC progression through nuclear factor kappa B signaling. Therefore, we concluded that CD147 promoted tumor progression in HNSCC and might be a potential prognostic and treatment biomarker for HNSCC. John Wiley and Sons Inc. 2018-11-12 2019-02 /pmc/articles/PMC6349162/ /pubmed/30421493 http://dx.doi.org/10.1111/jcmm.13996 Text en © 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Yu, Binbin
Zhang, Yan
Wu, Kailiu
Wang, Lizhen
Jiang, Yingying
Chen, Wantao
Yan, Ming
CD147 promotes progression of head and neck squamous cell carcinoma via NF‐kappa B signaling
title CD147 promotes progression of head and neck squamous cell carcinoma via NF‐kappa B signaling
title_full CD147 promotes progression of head and neck squamous cell carcinoma via NF‐kappa B signaling
title_fullStr CD147 promotes progression of head and neck squamous cell carcinoma via NF‐kappa B signaling
title_full_unstemmed CD147 promotes progression of head and neck squamous cell carcinoma via NF‐kappa B signaling
title_short CD147 promotes progression of head and neck squamous cell carcinoma via NF‐kappa B signaling
title_sort cd147 promotes progression of head and neck squamous cell carcinoma via nf‐kappa b signaling
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349162/
https://www.ncbi.nlm.nih.gov/pubmed/30421493
http://dx.doi.org/10.1111/jcmm.13996
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