TLR4-interacting SPA4 peptide improves host defense and alleviates tissue injury in a mouse model of Pseudomonas aeruginosa lung infection

Interaction between surfactant protein-A (SP-A) and toll-like receptor (TLR)4 plays a critical role in host defense. In this work, we studied the host defense function of SPA4 peptide (amino acids GDFRYSDGTPVNYTNWYRGE), derived from the TLR4-interacting region of SP-A, against Pseudomonas aeruginosa...

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Detalles Bibliográficos
Autores principales: Awasthi, Shanjana, Singh, Bhupinder, Ramani, Vijay, Xie, Jun, Kosanke, Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349318/
https://www.ncbi.nlm.nih.gov/pubmed/30689633
http://dx.doi.org/10.1371/journal.pone.0210979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349318/
https://www.ncbi.nlm.nih.gov/pubmed/30689633
http://dx.doi.org/10.1371/journal.pone.0210979

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