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Prenatal hypoxia plus postnatal high‐fat diet exacerbated vascular dysfunction via up‐regulated vascular Cav1.2 channels in offspring rats

BACKGROUND: This study aimed to examine whether and how postnatal high‐fat diet had additional impact on promoting vascular dysfunction in the offspring exposed to prenatal hypoxia. METHODS AND RESULTS: Pregnant Sprague‐Dawley rats were randomly assigned to hypoxia (10.5% oxygen) or normoxia (21% O(...

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Detalles Bibliográficos
Autores principales: Li, Xiang, Feng, Xueqin, Lu, Likui, He, Axin, Liu, Bailin, Zhang, Yingying, Shi, Ruixiu, Liu, Yanping, Chen, Xueyi, Sun, Miao, Xu, Zhice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349350/
https://www.ncbi.nlm.nih.gov/pubmed/30556291
http://dx.doi.org/10.1111/jcmm.14020