Mast cell tetrahydrobiopterin contributes to itch in mice

GTP cyclohydrolase (GCH1) governs de novo synthesis of the enzyme cofactor, tetrahydrobiopterin (BH4), which is essential for biogenic amine production, bioactive lipid metabolism and redox coupling of nitric oxide synthases. Overproduction of BH4 via upregulation of GCH1 in sensory neurons is assoc...

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Detalles Bibliográficos
Autores principales: Zschiebsch, Katja, Fischer, Caroline, Wilken‐Schmitz, Annett, Geisslinger, Gerd, Channon, Keith, Watschinger, Katrin, Tegeder, Irmgard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349351/
https://www.ncbi.nlm.nih.gov/pubmed/30450838
http://dx.doi.org/10.1111/jcmm.13999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349351/
https://www.ncbi.nlm.nih.gov/pubmed/30450838
http://dx.doi.org/10.1111/jcmm.13999

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