Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy

DUX4 is a transcription factor whose misexpression in skeletal muscle causes facioscapulohumeral muscular dystrophy (FSHD). DUX4’s transcriptional activity has been extensively characterized, but the DUX4-induced proteome remains undescribed. Here, we report concurrent measurement of RNA and protein...

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Detalles Bibliográficos
Autores principales: Jagannathan, Sujatha, Ogata, Yuko, Gafken, Philip R, Tapscott, Stephen J, Bradley, Robert K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349399/
https://www.ncbi.nlm.nih.gov/pubmed/30644821
http://dx.doi.org/10.7554/eLife.41740

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