Biological function and molecular mechanism of piRNA in cancer

Cancer is the second leading cause of death globally. piRNAs, which are a novel type of identified small noncoding RNA (ncRNA), play a crucial role in cancer genomics. In recent years, a relatively large number of studies have demonstrated that several piRNA are aberrantly expressed in various kinds...

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Detalles Bibliográficos
Autores principales: Chalbatani, Ghanbar Mahmoodi, Dana, Hassan, Memari, Feridon, Gharagozlou, Elahe, Ashjaei, Shirin, Kheirandish, Peyman, Marmari, Vahid, Mahmoudzadeh, Habibollah, Mozayani, Farnaz, Maleki, Ali Reza, Sadeghian, Ehsan, Nia, Elham Zainali, Miri, Seyed Rohollah, Nia, Neda zainali, Rezaeian, Omid, Eskandary, Anahita, Razavi, Narges, Shirkhoda, Mohammad, Rouzbahani, Fatemeh Nouri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349561/
https://www.ncbi.nlm.nih.gov/pubmed/30705933
http://dx.doi.org/10.1016/j.plabm.2018.e00113
Descripción
Sumario:Cancer is the second leading cause of death globally. piRNAs, which are a novel type of identified small noncoding RNA (ncRNA), play a crucial role in cancer genomics. In recent years, a relatively large number of studies have demonstrated that several piRNA are aberrantly expressed in various kinds of cancers including gastric cancer, bladder cancer, breast cancer, colorectal cancer and Lung cancer and may probably serve as a novel therapeutic target and biomarker for cancer treatment. The present review summarized current advances in our knowledge of the roles of piRNAs in cancer.

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