Subcutaneous Administration of PDGF-AA Improves the Functional Recovery After Spinal Cord Injury

Previous studies by our group have demonstrated that the transplantation of exogenous platelet-derived growth factor (PDGF)-AA-overexpressing oligodendrocyte progenitor cells (OPCs) promotes tissue repair and recovery of neurological function in a rat model of spinal cord injury (SCI). However, it r...

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Autores principales: Guo, Xue-Yan, Duan, Fei-Xiang, Chen, Jing, Wang, Ying, Wang, Rui, Shen, Lin, Qi, Qi, Jiang, Zhi-Quan, Zhu, An-You, Xi, Jin, Lü, He-Zuo, Hu, Jian-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349709/
https://www.ncbi.nlm.nih.gov/pubmed/30723394
http://dx.doi.org/10.3389/fnins.2019.00006
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author Guo, Xue-Yan
Duan, Fei-Xiang
Chen, Jing
Wang, Ying
Wang, Rui
Shen, Lin
Qi, Qi
Jiang, Zhi-Quan
Zhu, An-You
Xi, Jin
Lü, He-Zuo
Hu, Jian-Guo
author_facet Guo, Xue-Yan
Duan, Fei-Xiang
Chen, Jing
Wang, Ying
Wang, Rui
Shen, Lin
Qi, Qi
Jiang, Zhi-Quan
Zhu, An-You
Xi, Jin
Lü, He-Zuo
Hu, Jian-Guo
author_sort Guo, Xue-Yan
collection PubMed
description Previous studies by our group have demonstrated that the transplantation of exogenous platelet-derived growth factor (PDGF)-AA-overexpressing oligodendrocyte progenitor cells (OPCs) promotes tissue repair and recovery of neurological function in a rat model of spinal cord injury (SCI). However, it remains unclear whether treatment with PDGF-AA also affects endogenous oligodendrocytes (OLs) or even neurons, thus promoting further functional recovery after SCI. In the present study, we evaluated the therapeutic potential of PDGF-AA treatment by direct subcutaneous injection of PDGF-AA immediately after SCI. We demonstrated that PDGF-AA injection resulted in increased tissue sparing, myelination and functional recovery in rats following SCI. Further experimentation confirmed that PDGF-AA increased the survival of endogenous OPCs and OLs, and promoted the proliferation of OPCs and their differentiation into OLs. Moreover, PDGF-AA also protected motor neurons from death in the injured spinal cord. These results indicated that PDGF-AA administration may be an effective treatment for SCI.
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spelling pubmed-63497092019-02-05 Subcutaneous Administration of PDGF-AA Improves the Functional Recovery After Spinal Cord Injury Guo, Xue-Yan Duan, Fei-Xiang Chen, Jing Wang, Ying Wang, Rui Shen, Lin Qi, Qi Jiang, Zhi-Quan Zhu, An-You Xi, Jin Lü, He-Zuo Hu, Jian-Guo Front Neurosci Neuroscience Previous studies by our group have demonstrated that the transplantation of exogenous platelet-derived growth factor (PDGF)-AA-overexpressing oligodendrocyte progenitor cells (OPCs) promotes tissue repair and recovery of neurological function in a rat model of spinal cord injury (SCI). However, it remains unclear whether treatment with PDGF-AA also affects endogenous oligodendrocytes (OLs) or even neurons, thus promoting further functional recovery after SCI. In the present study, we evaluated the therapeutic potential of PDGF-AA treatment by direct subcutaneous injection of PDGF-AA immediately after SCI. We demonstrated that PDGF-AA injection resulted in increased tissue sparing, myelination and functional recovery in rats following SCI. Further experimentation confirmed that PDGF-AA increased the survival of endogenous OPCs and OLs, and promoted the proliferation of OPCs and their differentiation into OLs. Moreover, PDGF-AA also protected motor neurons from death in the injured spinal cord. These results indicated that PDGF-AA administration may be an effective treatment for SCI. Frontiers Media S.A. 2019-01-22 /pmc/articles/PMC6349709/ /pubmed/30723394 http://dx.doi.org/10.3389/fnins.2019.00006 Text en Copyright © 2019 Guo, Duan, Chen, Wang, Wang, Shen, Qi, Jiang, Zhu, Xi, Lü and Hu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Guo, Xue-Yan
Duan, Fei-Xiang
Chen, Jing
Wang, Ying
Wang, Rui
Shen, Lin
Qi, Qi
Jiang, Zhi-Quan
Zhu, An-You
Xi, Jin
Lü, He-Zuo
Hu, Jian-Guo
Subcutaneous Administration of PDGF-AA Improves the Functional Recovery After Spinal Cord Injury
title Subcutaneous Administration of PDGF-AA Improves the Functional Recovery After Spinal Cord Injury
title_full Subcutaneous Administration of PDGF-AA Improves the Functional Recovery After Spinal Cord Injury
title_fullStr Subcutaneous Administration of PDGF-AA Improves the Functional Recovery After Spinal Cord Injury
title_full_unstemmed Subcutaneous Administration of PDGF-AA Improves the Functional Recovery After Spinal Cord Injury
title_short Subcutaneous Administration of PDGF-AA Improves the Functional Recovery After Spinal Cord Injury
title_sort subcutaneous administration of pdgf-aa improves the functional recovery after spinal cord injury
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349709/
https://www.ncbi.nlm.nih.gov/pubmed/30723394
http://dx.doi.org/10.3389/fnins.2019.00006
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