IFNβ enhances mesenchymal stromal (Stem) cells immunomodulatory function through STAT1-3 activation and mTOR-associated promotion of glucose metabolism

Administration of mesenchymal stem cells (MSC) ameliorate experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS), at both clinical and neuropathological levels. The therapeutic properties of MSC in EAE are mainly mediated by the modulation of pathogenic immune resp...

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Detalles Bibliográficos
Autores principales: Vigo, Tiziana, La Rocca, Claudia, Faicchia, Deriggio, Procaccini, Claudio, Ruggieri, Maddalena, Salvetti, Marco, Centonze, Diego, Matarese, Giuseppe, Uccelli, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349843/
https://www.ncbi.nlm.nih.gov/pubmed/30692524
http://dx.doi.org/10.1038/s41419-019-1336-4

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