Overcoming NADPH product inhibition improves D-sorbitol conversion to L-sorbose

Gluconobacter oxydans sorbitol dehydrogenase (GoSLDH) exhibits a higher catalytic efficiency than other l-sorbose producing enzymes. During the reaction catalysed by GoSLDH, NADP(+) is reduced to NADPH and d-sorbitol is oxidized to l-sorbose. However, GoSLDH activity is inhibited by the NADPH (K(i) ...

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Detalles Bibliográficos
Autores principales: Kim, Tae-Su, Gao, Hui, Li, Jinglin, Kalia, Vipin C., Muthusamy, Karthikeyan, Sohng, Jae Kyung, Kim, In-Won, Lee, Jung-Kul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349845/
https://www.ncbi.nlm.nih.gov/pubmed/30692560
http://dx.doi.org/10.1038/s41598-018-37401-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349845/
https://www.ncbi.nlm.nih.gov/pubmed/30692560
http://dx.doi.org/10.1038/s41598-018-37401-0

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