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Directed evolution of super-secreted variants from phage-displayed human Interleukin-2

Selection from a phage display library derived from human Interleukin-2 (IL-2) yielded mutated variants with greatly enhanced display levels of the functional cytokine on filamentous phages. Introduction of a single amino acid replacement selected that way (K35E) increased the secretion levels of IL...

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Detalles Bibliográficos
Autores principales:	Rojas, Gertrudis, Carmenate, Tania, Santo-Tomás, Julio Felipe, Valiente, Pedro A., Becker, Marlies, Pérez-Riverón, Annia, Tundidor, Yaima, Ortiz, Yaquelín, Fernandez de Cossio-Diaz, Jorge, Graça, Luis, Dübel, Stefan, León, Kalet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349883/ https://www.ncbi.nlm.nih.gov/pubmed/30692603 http://dx.doi.org/10.1038/s41598-018-37280-5

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