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Induction of 3-hydroxy-3-methylglutaryl-CoA reductase mediates statin resistance in breast cancer cells

The mevalonate pathway has emerged as a promising target for several solid tumors. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme of this pathway, and are commonly used to treat patients with hypercholesterolemia. Pleiotropic antitumor mechan...

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Detalles Bibliográficos
Autores principales:	Göbel, Andy, Breining, Dorit, Rauner, Martina, Hofbauer, Lorenz C., Rachner, Tilman D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349912/ https://www.ncbi.nlm.nih.gov/pubmed/30692522 http://dx.doi.org/10.1038/s41419-019-1322-x

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