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A five-residue motif for the design of domain swapping in proteins

Domain swapping is the process by which identical monomeric proteins exchange structural elements to generate dimers/oligomers. Although engineered domain swapping is a compelling strategy for protein assembly, its application has been limited due to the lack of simple and reliable design approaches...

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Detalles Bibliográficos
Autores principales: Nandwani, Neha, Surana, Parag, Negi, Hitendra, Mascarenhas, Nahren M., Udgaonkar, Jayant B., Das, Ranabir, Gosavi, Shachi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349918/
https://www.ncbi.nlm.nih.gov/pubmed/30692525
http://dx.doi.org/10.1038/s41467-019-08295-x