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High cholesterol triggers white matter alterations and cognitive deficits in a mouse model of cerebrovascular disease: benefits of simvastatin

Transgenic mice overexpressing transforming growth factor-β1 (TGF mice) display impaired cerebrovascular reactivity, cerebral hypoperfusion and neurovascular uncoupling, but no overt cognitive deficits until old age. Cardiovascular diseases are a major risk factor for vascular cognitive impairment a...

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Detalles Bibliográficos
Autores principales:	Tong, Xin-Kang, Trigiani, Lianne J., Hamel, Edith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349936/ https://www.ncbi.nlm.nih.gov/pubmed/30692517 http://dx.doi.org/10.1038/s41419-018-1199-0

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