PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

Alzheimer’s disease (AD) is a heterogeneous disorder with multiple etiologies. Harnessing the immune system by blocking the programmed cell death receptor (PD)-1 pathway in an amyloid beta mouse model was shown to evoke a sequence of immune responses that lead to disease modification. Here, blocking...

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Detalles Bibliográficos
Autores principales: Rosenzweig, Neta, Dvir-Szternfeld, Raz, Tsitsou-Kampeli, Afroditi, Keren-Shaul, Hadas, Ben-Yehuda, Hila, Weill-Raynal, Pierre, Cahalon, Liora, Kertser, Alex, Baruch, Kuti, Amit, Ido, Weiner, Assaf, Schwartz, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349941/
https://www.ncbi.nlm.nih.gov/pubmed/30692527
http://dx.doi.org/10.1038/s41467-019-08352-5

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