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Parity Differently Affects the Breast Cancer Specific Survival from Ductal Carcinoma In Situ to Invasive Cancer: A Registry-Based Retrospective Study from Korea
PURPOSE: Multiparity might increase general mortality for women, but has inconclusive in patients with breast cancer. Here, we aim to discover their effect in terms of the breast cancer development hypothesis: from ductal carcinoma in situ to invasive carcinoma. METHODS: We included 37 947 patients...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350119/ https://www.ncbi.nlm.nih.gov/pubmed/30728717 http://dx.doi.org/10.1177/1178223418825134 |
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author | Lee, JungSun Oh, Minkyung Ko, SeungSang Park, Chanheun Lee, Eun Sook Kim, Hyun-Ah Jung, Yongsik Lee, Jungyeon |
author_facet | Lee, JungSun Oh, Minkyung Ko, SeungSang Park, Chanheun Lee, Eun Sook Kim, Hyun-Ah Jung, Yongsik Lee, Jungyeon |
author_sort | Lee, JungSun |
collection | PubMed |
description | PURPOSE: Multiparity might increase general mortality for women, but has inconclusive in patients with breast cancer. Here, we aim to discover their effect in terms of the breast cancer development hypothesis: from ductal carcinoma in situ to invasive carcinoma. METHODS: We included 37 947 patients from the web-based breast cancer registration program of the Korean Breast Cancer Society and analyzed survivals using multivariate Cox regression analysis and whether the associations of these factors displayed linear trends. They were divided into the following groups: (1) pure ductal carcinoma in situ (DCIS), (2) invasive ductal carcinoma (IDC) mixed with intraductal component (DCIS-IDC), and (3) node negative pure IDC. RESULTS: The mean age was 48.9 ± 9.9 years including premenopausal women was 61.8%. Although patients with parities of 1-3 had better prognosis compared with patients with nulliparous women, high parity (⩾4) increased the hazard ratio (HR) of overall survival (OS) (DCIS: HR, 1.52; 95% confidence interval [CI] 0.62-3.78; IDC: HR, 1.43, 95% CI 0.89-2.31; and DCIS-IDC: HR, 1.44, 95% CI 0.45-4.59) during 84.2 (±10.7) months. For breast cancer specific survival (BCSS), the HR of the IDC group (P-value for trend = .04) increased along with increasing parity and was worse than nulliparous patients, and the HR of the DCIS-IDC group increased but was better than nulliparous patients (P-value for trend = .02). Compared with nulliparous patients, any age at first birth (AFB) decreased HR of OS in the DCIS and IDC groups (DCIS: P = .01; IDC: P = .04). CONCLUSIONS: Parity show dual effects on OS of women with all ductal typed breast cancer but show different effects on BCSS in Korea. |
format | Online Article Text |
id | pubmed-6350119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-63501192019-02-06 Parity Differently Affects the Breast Cancer Specific Survival from Ductal Carcinoma In Situ to Invasive Cancer: A Registry-Based Retrospective Study from Korea Lee, JungSun Oh, Minkyung Ko, SeungSang Park, Chanheun Lee, Eun Sook Kim, Hyun-Ah Jung, Yongsik Lee, Jungyeon Breast Cancer (Auckl) Original Research PURPOSE: Multiparity might increase general mortality for women, but has inconclusive in patients with breast cancer. Here, we aim to discover their effect in terms of the breast cancer development hypothesis: from ductal carcinoma in situ to invasive carcinoma. METHODS: We included 37 947 patients from the web-based breast cancer registration program of the Korean Breast Cancer Society and analyzed survivals using multivariate Cox regression analysis and whether the associations of these factors displayed linear trends. They were divided into the following groups: (1) pure ductal carcinoma in situ (DCIS), (2) invasive ductal carcinoma (IDC) mixed with intraductal component (DCIS-IDC), and (3) node negative pure IDC. RESULTS: The mean age was 48.9 ± 9.9 years including premenopausal women was 61.8%. Although patients with parities of 1-3 had better prognosis compared with patients with nulliparous women, high parity (⩾4) increased the hazard ratio (HR) of overall survival (OS) (DCIS: HR, 1.52; 95% confidence interval [CI] 0.62-3.78; IDC: HR, 1.43, 95% CI 0.89-2.31; and DCIS-IDC: HR, 1.44, 95% CI 0.45-4.59) during 84.2 (±10.7) months. For breast cancer specific survival (BCSS), the HR of the IDC group (P-value for trend = .04) increased along with increasing parity and was worse than nulliparous patients, and the HR of the DCIS-IDC group increased but was better than nulliparous patients (P-value for trend = .02). Compared with nulliparous patients, any age at first birth (AFB) decreased HR of OS in the DCIS and IDC groups (DCIS: P = .01; IDC: P = .04). CONCLUSIONS: Parity show dual effects on OS of women with all ductal typed breast cancer but show different effects on BCSS in Korea. SAGE Publications 2019-01-27 /pmc/articles/PMC6350119/ /pubmed/30728717 http://dx.doi.org/10.1177/1178223418825134 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Lee, JungSun Oh, Minkyung Ko, SeungSang Park, Chanheun Lee, Eun Sook Kim, Hyun-Ah Jung, Yongsik Lee, Jungyeon Parity Differently Affects the Breast Cancer Specific Survival from Ductal Carcinoma In Situ to Invasive Cancer: A Registry-Based Retrospective Study from Korea |
title | Parity Differently Affects the Breast Cancer Specific Survival from
Ductal Carcinoma In Situ to Invasive Cancer: A Registry-Based Retrospective
Study from Korea |
title_full | Parity Differently Affects the Breast Cancer Specific Survival from
Ductal Carcinoma In Situ to Invasive Cancer: A Registry-Based Retrospective
Study from Korea |
title_fullStr | Parity Differently Affects the Breast Cancer Specific Survival from
Ductal Carcinoma In Situ to Invasive Cancer: A Registry-Based Retrospective
Study from Korea |
title_full_unstemmed | Parity Differently Affects the Breast Cancer Specific Survival from
Ductal Carcinoma In Situ to Invasive Cancer: A Registry-Based Retrospective
Study from Korea |
title_short | Parity Differently Affects the Breast Cancer Specific Survival from
Ductal Carcinoma In Situ to Invasive Cancer: A Registry-Based Retrospective
Study from Korea |
title_sort | parity differently affects the breast cancer specific survival from
ductal carcinoma in situ to invasive cancer: a registry-based retrospective
study from korea |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350119/ https://www.ncbi.nlm.nih.gov/pubmed/30728717 http://dx.doi.org/10.1177/1178223418825134 |
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