Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?

BACKGROUND: Progressive solitary sclerosis is a unifocal demyelinating disease recently proposed as a possible multiple sclerosis variant. OBJECTIVE: To compare myelin content and brain metabolite ratio qualitatively in the normal-appearing white matter of progressive solitary sclerosis cases compar...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Lisa Eunyoung, Chan, Jillian K, Nevill, Emilie, Soares, Adam, Vavasour, Irene M, MacMillan, Erin L, Garren, Hideki, Clayton, David, Keegan, B Mark, Tam, Roger, Traboulsee, Anthony L, Kolind, Shannon H, Carruthers, Robert L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350151/
https://www.ncbi.nlm.nih.gov/pubmed/30729027
http://dx.doi.org/10.1177/2055217318824612
Descripción
Sumario:BACKGROUND: Progressive solitary sclerosis is a unifocal demyelinating disease recently proposed as a possible multiple sclerosis variant. OBJECTIVE: To compare myelin content and brain metabolite ratio qualitatively in the normal-appearing white matter of progressive solitary sclerosis cases compared to multiple sclerosis and healthy control participants. METHODS: Case report. RESULTS: Progressive solitary sclerosis cases showed abnormal myelin in normal-appearing white matter tracts and global normal-appearing white matter as well as lower N-acetyl-aspartate to total creatine ratio compared to multiple sclerosis and healthy control groups. CONCLUSION: Despite a single demyelinating lesion along the corticospinal tract in progressive solitary sclerosis, we showed evidence of more extensive abnormality within the normal-appearing white matter.

Ejemplares similares