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Cytochrome P450 3A4 Induction: Lumacaftor versus Ivacaftor Potentially Resulting in Significantly Reduced Plasma Concentration of Ivacaftor
BACKGROUND & OBJECTIVE: Since the release of ivacaftor-lumacaftor, several red-flags have been raised that highlight the clinical efficacy of this combination strategy that may be limited due to an-tagonistic drug-drug interactions. METHOD: The effect of ivacaftor, its major metabolites M1 and M...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Bentham Science Publishers
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350194/ https://www.ncbi.nlm.nih.gov/pubmed/29595119 http://dx.doi.org/10.2174/1872312812666180328105259 |