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Trans-ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Gene Transduction after Intravitreal Vector Administration

Adeno-associated virus (AAV) vector-mediated gene delivery is a promising approach for therapy, but implementation in the eye currently is hampered by the need for delivering the vector underneath the retina, using surgical application into the subretinal space. This limits the extent of the retina...

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Detalles Bibliográficos
Autores principales:	Song, Hongman, Bush, Ronald A., Zeng, Yong, Qian, Haohua, Wu, Zhijian, Sieving, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350231/ https://www.ncbi.nlm.nih.gov/pubmed/30719486 http://dx.doi.org/10.1016/j.omtm.2018.12.006

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