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Does artemether–lumefantrine administration affect mosquito olfactory behaviour and fitness?

BACKGROUND: Artemisinin-based combination therapy (ACT) is the recommended treatment against uncomplicated Plasmodium falciparum infections, and ACT is widely used. It has been shown that gametocytes may be present after ACT and transmission to mosquitoes is still possible. Artemether–lumefantrine (...

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Autores principales: de Boer, Jetske G., Busula, Annette O., ten Berge, Jet, van Dijk, Tessa S., Takken, Willem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350316/
https://www.ncbi.nlm.nih.gov/pubmed/30691446
http://dx.doi.org/10.1186/s12936-019-2646-9
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author de Boer, Jetske G.
Busula, Annette O.
ten Berge, Jet
van Dijk, Tessa S.
Takken, Willem
author_facet de Boer, Jetske G.
Busula, Annette O.
ten Berge, Jet
van Dijk, Tessa S.
Takken, Willem
author_sort de Boer, Jetske G.
collection PubMed
description BACKGROUND: Artemisinin-based combination therapy (ACT) is the recommended treatment against uncomplicated Plasmodium falciparum infections, and ACT is widely used. It has been shown that gametocytes may be present after ACT and transmission to mosquitoes is still possible. Artemether–lumefantrine (AL) is a broadly used artemisinin-based combination medicine. Here, it is tested whether AL influences behaviour and fitness of Anopheles mosquitoes, which are the main vectors of P. falciparum. RESULTS: Dual-choice olfactometer and screenhouse experiments showed that skin odour of healthy human individuals obtained before, during and after AL-administration was equally attractive to Anopheles coluzzii and Anopheles gambiae sensu stricto, apart from a small (but significant) increase in mosquito response to skin odour collected 3 weeks after AL-administration. Anopheles coluzzii females fed on parasite-free blood supplemented with AL or on control-blood had similar survival, time until oviposition and number of eggs produced. CONCLUSIONS: Based on the results, AL does not appear to influence malaria transmission through modification of vector mosquito olfactory behaviour or fitness. Extending these studies to Plasmodium-infected individuals and malaria mosquitoes with parasites are needed to further support this conclusion. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12936-019-2646-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-63503162019-02-04 Does artemether–lumefantrine administration affect mosquito olfactory behaviour and fitness? de Boer, Jetske G. Busula, Annette O. ten Berge, Jet van Dijk, Tessa S. Takken, Willem Malar J Research BACKGROUND: Artemisinin-based combination therapy (ACT) is the recommended treatment against uncomplicated Plasmodium falciparum infections, and ACT is widely used. It has been shown that gametocytes may be present after ACT and transmission to mosquitoes is still possible. Artemether–lumefantrine (AL) is a broadly used artemisinin-based combination medicine. Here, it is tested whether AL influences behaviour and fitness of Anopheles mosquitoes, which are the main vectors of P. falciparum. RESULTS: Dual-choice olfactometer and screenhouse experiments showed that skin odour of healthy human individuals obtained before, during and after AL-administration was equally attractive to Anopheles coluzzii and Anopheles gambiae sensu stricto, apart from a small (but significant) increase in mosquito response to skin odour collected 3 weeks after AL-administration. Anopheles coluzzii females fed on parasite-free blood supplemented with AL or on control-blood had similar survival, time until oviposition and number of eggs produced. CONCLUSIONS: Based on the results, AL does not appear to influence malaria transmission through modification of vector mosquito olfactory behaviour or fitness. Extending these studies to Plasmodium-infected individuals and malaria mosquitoes with parasites are needed to further support this conclusion. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12936-019-2646-9) contains supplementary material, which is available to authorized users. BioMed Central 2019-01-28 /pmc/articles/PMC6350316/ /pubmed/30691446 http://dx.doi.org/10.1186/s12936-019-2646-9 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
de Boer, Jetske G.
Busula, Annette O.
ten Berge, Jet
van Dijk, Tessa S.
Takken, Willem
Does artemether–lumefantrine administration affect mosquito olfactory behaviour and fitness?
title Does artemether–lumefantrine administration affect mosquito olfactory behaviour and fitness?
title_full Does artemether–lumefantrine administration affect mosquito olfactory behaviour and fitness?
title_fullStr Does artemether–lumefantrine administration affect mosquito olfactory behaviour and fitness?
title_full_unstemmed Does artemether–lumefantrine administration affect mosquito olfactory behaviour and fitness?
title_short Does artemether–lumefantrine administration affect mosquito olfactory behaviour and fitness?
title_sort does artemether–lumefantrine administration affect mosquito olfactory behaviour and fitness?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350316/
https://www.ncbi.nlm.nih.gov/pubmed/30691446
http://dx.doi.org/10.1186/s12936-019-2646-9
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