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Knockdown of FOXO3a induces epithelial-mesenchymal transition and promotes metastasis of pancreatic ductal adenocarcinoma by activation of the β-catenin/TCF4 pathway through SPRY2

BACKGROUND: Early invasion and metastasis are responsible for the dismal prognosis of pancreatic ductal adenocarcinoma (PDAC), and epithelial-to-mesenchymal transition (EMT) is recognized as a crucial biological progress in driving tumor invasion and metastasis. The transcription factor FOXO3a is in...

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Detalles Bibliográficos
Autores principales:	Li, Jun, Yang, Rumeng, Dong, Yuting, Chen, Manyao, Wang, Yu, Wang, Guoping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350320/ https://www.ncbi.nlm.nih.gov/pubmed/30691517 http://dx.doi.org/10.1186/s13046-019-1046-x

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