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Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review

Viral encephalitis and glioblastoma are both relatively rare conditions with poor prognoses. While the clinical and radiographic presentations of these diseases are often distinctly different, viral encephalitis can sometimes masquerade as glioblastoma. Rarely, glioblastoma can also be misdiagnosed...

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Autores principales: Piper, Keenan, Foster, Haidn, Gabel, Brandon, Nabors, Burt, Cobbs, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350341/
https://www.ncbi.nlm.nih.gov/pubmed/30723703
http://dx.doi.org/10.3389/fonc.2019.00008
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author Piper, Keenan
Foster, Haidn
Gabel, Brandon
Nabors, Burt
Cobbs, Charles
author_facet Piper, Keenan
Foster, Haidn
Gabel, Brandon
Nabors, Burt
Cobbs, Charles
author_sort Piper, Keenan
collection PubMed
description Viral encephalitis and glioblastoma are both relatively rare conditions with poor prognoses. While the clinical and radiographic presentations of these diseases are often distinctly different, viral encephalitis can sometimes masquerade as glioblastoma. Rarely, glioblastoma can also be misdiagnosed as viral encephalitis. In some cases where a high-grade glioma was initially diagnosed as viral encephalitis, antiviral administration has proven effective for relieving early symptoms. We present three cases in which patients presented with symptoms and radiographic findings suggestive of viral encephalitis and experienced dramatic clinical improvement following treatment with acyclovir, only to later be diagnosed with glioblastoma in the region of suspected encephalitis and ultimately succumb to tumor progression.
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spelling pubmed-63503412019-02-05 Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review Piper, Keenan Foster, Haidn Gabel, Brandon Nabors, Burt Cobbs, Charles Front Oncol Oncology Viral encephalitis and glioblastoma are both relatively rare conditions with poor prognoses. While the clinical and radiographic presentations of these diseases are often distinctly different, viral encephalitis can sometimes masquerade as glioblastoma. Rarely, glioblastoma can also be misdiagnosed as viral encephalitis. In some cases where a high-grade glioma was initially diagnosed as viral encephalitis, antiviral administration has proven effective for relieving early symptoms. We present three cases in which patients presented with symptoms and radiographic findings suggestive of viral encephalitis and experienced dramatic clinical improvement following treatment with acyclovir, only to later be diagnosed with glioblastoma in the region of suspected encephalitis and ultimately succumb to tumor progression. Frontiers Media S.A. 2019-01-22 /pmc/articles/PMC6350341/ /pubmed/30723703 http://dx.doi.org/10.3389/fonc.2019.00008 Text en Copyright © 2019 Piper, Foster, Gabel, Nabors and Cobbs. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Piper, Keenan
Foster, Haidn
Gabel, Brandon
Nabors, Burt
Cobbs, Charles
Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review
title Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review
title_full Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review
title_fullStr Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review
title_full_unstemmed Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review
title_short Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review
title_sort glioblastoma mimicking viral encephalitis responds to acyclovir: a case series and literature review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350341/
https://www.ncbi.nlm.nih.gov/pubmed/30723703
http://dx.doi.org/10.3389/fonc.2019.00008
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