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Comparative functional genomics of the acarbose producers reveals potential targets for metabolic engineering

The α-glucosidase inhibitor acarbose is produced in large-scale by strains derived from Actinoplanes sp. SE50 and used widely for the treatment of type-2 diabetes. Compared with the wild-type SE50, a high-yield derivative Actinoplanes sp. SE50/110 shows 2-fold and 3–7-fold improvement of acarbose yi...

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Detalles Bibliográficos
Autores principales:	Xie, Huixin, Zhao, Qinqin, Zhang, Xin, Kang, Qianjin, Bai, Linquan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	KeAi Publishing 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350373/ https://www.ncbi.nlm.nih.gov/pubmed/30723817 http://dx.doi.org/10.1016/j.synbio.2019.01.001

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