Cargando…

Neurophysiologic and Cognitive Changes Arising from Cognitive Training Interventions in Persons with Mild Cognitive Impairment: A Systematic Review

BACKGROUND: Previous reviews have generally reported cognitive//behavioral improvements after cognitively oriented treatments (COTs) in persons with MCI. However, comparatively little is known about the neural mechanisms associated with such cognitive improvement. OBJECTIVE: The primary aim of the c...

Descripción completa

Detalles Bibliográficos
Autores principales: Miotto, Eliane C., Batista, Alana X., Simon, Sharon S., Hampstead, Benjamin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350540/
https://www.ncbi.nlm.nih.gov/pubmed/30766600
http://dx.doi.org/10.1155/2018/7301530
_version_ 1783390463716229120
author Miotto, Eliane C.
Batista, Alana X.
Simon, Sharon S.
Hampstead, Benjamin M.
author_facet Miotto, Eliane C.
Batista, Alana X.
Simon, Sharon S.
Hampstead, Benjamin M.
author_sort Miotto, Eliane C.
collection PubMed
description BACKGROUND: Previous reviews have generally reported cognitive//behavioral improvements after cognitively oriented treatments (COTs) in persons with MCI. However, comparatively little is known about the neural mechanisms associated with such cognitive improvement. OBJECTIVE: The primary aim of the current review was to examine neurophysiological changes measured by functional magnetic resonance imaging (fMRI) and possible cognitive changes following COTs in those with MCI. Methods. An extensive literature search was conducted up to August 2018. Inclusion criteria were (1) studies that evaluated the effects of the COTs in patients with amnestic single- or multiple-domain MCI using fMRI, (2) the MCI patient sample having met Petersen's or Jack/Bond's criteria, (3) randomized and/or controlled trials, (4) fMRI and cognitive assessments completed pre- and post-intervention, and (5) articles available in English. RESULTS: Amongst the 26 articles found, 7 studies were included according to the above inclusion criteria. A total of 3 studies applied rehearsal-based strategies as the primary intervention, all of which used computerized cognitive training. Four studies used fMRI to investigate the neurophysiologic and cognitive changes associated with memory strategy training. The majority of the studies included in this review showed evidence of improved objective cognitive performance associated with COTs, even in tasks similar to everyday life activities. In addition, there were significant changes in brain activation associated with interventions, in both typical and atypical brain areas and networks related to memory. CONCLUSIONS: Although additional studies are needed given the small sample size, these initial findings suggest that cognitive improvement after COTs is generally associated with both compensatory (i.e., engaging alternative brain regions or networks not “typically” engaged) and restorative (i.e., reengaging the “typical” brain regions or networks) mechanisms.
format Online
Article
Text
id pubmed-6350540
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-63505402019-02-14 Neurophysiologic and Cognitive Changes Arising from Cognitive Training Interventions in Persons with Mild Cognitive Impairment: A Systematic Review Miotto, Eliane C. Batista, Alana X. Simon, Sharon S. Hampstead, Benjamin M. Neural Plast Review Article BACKGROUND: Previous reviews have generally reported cognitive//behavioral improvements after cognitively oriented treatments (COTs) in persons with MCI. However, comparatively little is known about the neural mechanisms associated with such cognitive improvement. OBJECTIVE: The primary aim of the current review was to examine neurophysiological changes measured by functional magnetic resonance imaging (fMRI) and possible cognitive changes following COTs in those with MCI. Methods. An extensive literature search was conducted up to August 2018. Inclusion criteria were (1) studies that evaluated the effects of the COTs in patients with amnestic single- or multiple-domain MCI using fMRI, (2) the MCI patient sample having met Petersen's or Jack/Bond's criteria, (3) randomized and/or controlled trials, (4) fMRI and cognitive assessments completed pre- and post-intervention, and (5) articles available in English. RESULTS: Amongst the 26 articles found, 7 studies were included according to the above inclusion criteria. A total of 3 studies applied rehearsal-based strategies as the primary intervention, all of which used computerized cognitive training. Four studies used fMRI to investigate the neurophysiologic and cognitive changes associated with memory strategy training. The majority of the studies included in this review showed evidence of improved objective cognitive performance associated with COTs, even in tasks similar to everyday life activities. In addition, there were significant changes in brain activation associated with interventions, in both typical and atypical brain areas and networks related to memory. CONCLUSIONS: Although additional studies are needed given the small sample size, these initial findings suggest that cognitive improvement after COTs is generally associated with both compensatory (i.e., engaging alternative brain regions or networks not “typically” engaged) and restorative (i.e., reengaging the “typical” brain regions or networks) mechanisms. Hindawi 2018-12-02 /pmc/articles/PMC6350540/ /pubmed/30766600 http://dx.doi.org/10.1155/2018/7301530 Text en Copyright © 2018 Eliane C. Miotto et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Miotto, Eliane C.
Batista, Alana X.
Simon, Sharon S.
Hampstead, Benjamin M.
Neurophysiologic and Cognitive Changes Arising from Cognitive Training Interventions in Persons with Mild Cognitive Impairment: A Systematic Review
title Neurophysiologic and Cognitive Changes Arising from Cognitive Training Interventions in Persons with Mild Cognitive Impairment: A Systematic Review
title_full Neurophysiologic and Cognitive Changes Arising from Cognitive Training Interventions in Persons with Mild Cognitive Impairment: A Systematic Review
title_fullStr Neurophysiologic and Cognitive Changes Arising from Cognitive Training Interventions in Persons with Mild Cognitive Impairment: A Systematic Review
title_full_unstemmed Neurophysiologic and Cognitive Changes Arising from Cognitive Training Interventions in Persons with Mild Cognitive Impairment: A Systematic Review
title_short Neurophysiologic and Cognitive Changes Arising from Cognitive Training Interventions in Persons with Mild Cognitive Impairment: A Systematic Review
title_sort neurophysiologic and cognitive changes arising from cognitive training interventions in persons with mild cognitive impairment: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350540/
https://www.ncbi.nlm.nih.gov/pubmed/30766600
http://dx.doi.org/10.1155/2018/7301530
work_keys_str_mv AT miottoelianec neurophysiologicandcognitivechangesarisingfromcognitivetraininginterventionsinpersonswithmildcognitiveimpairmentasystematicreview
AT batistaalanax neurophysiologicandcognitivechangesarisingfromcognitivetraininginterventionsinpersonswithmildcognitiveimpairmentasystematicreview
AT simonsharons neurophysiologicandcognitivechangesarisingfromcognitivetraininginterventionsinpersonswithmildcognitiveimpairmentasystematicreview
AT hampsteadbenjaminm neurophysiologicandcognitivechangesarisingfromcognitivetraininginterventionsinpersonswithmildcognitiveimpairmentasystematicreview