Cargando…

Degradation Characteristics of a Novel PAF Receptor Antagonist, SY0916, in Aqueous Solution

SY0916 has been proven to be a potent treatment agent against rheumatoid arthritis in preclinical studies and has been shown to be safe in phase I clinical trials. However, SY0916 is unstable in water, which is frequently used in pharmaceutical development processes. The degradation behaviour and st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Bo, Wang, Yanan, Zhang, Tingting, Yin, Wanting, Zhang, Dongfeng, Huang, Haihong, Ma, Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350595/ https://www.ncbi.nlm.nih.gov/pubmed/30766739 http://dx.doi.org/10.1155/2019/8789470

Ejemplares similares

PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: Cell and nuclear effects
por: Sharif, Najam A.
Publicado: (2022)

Complete Genome Sequence of Weissella hellenica 0916-4-2 and Its Comparative Genomic Analysis
por: Panthee, Suresh, et al.
Publicado: (2019)

SP_0916 Is an Arginine Decarboxylase That Catalyzes the Synthesis of Agmatine, Which Is Critical for Capsule Biosynthesis in Streptococcus pneumoniae
por: Ayoola, Moses B., et al.
Publicado: (2020)

First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors
por: Kim, Tae Won, et al.
Publicado: (2022)

Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects
por: Shamizadeh, Soja, et al.
Publicado: (2014)

Antiplatelet Aggregation and Platelet Activating Factor (PAF) Receptor Antagonistic Activities of the Essential Oils of Five Goniothalamus Species
por: Moharam, Bushra Abdulkarim, et al.
Publicado: (2010)

Combined Therapy With Avastin, a PAF Receptor Antagonist and a Lipid Mediator Inhibited Glioblastoma Tumor Growth
por: Cruz Flores, Valerie A., et al.
Publicado: (2021)

Photocatalytic degradation of diphenhydramine in aqueous solution by natural dolomite
por: Song, Lihong, et al.
Publicado: (2020)

Degradation Kinetics of Benzyl Nicotinate in Aqueous Solution
por: Mbah, C. J.
Publicado: (2010)

Photo- and Thermal Degradation of Piroxicam in Aqueous Solution
por: Aminuddin, M., et al.
Publicado: (2011)

Increased susceptibility to bladder inflammation in smokers: targeting the PAF–PAF receptor interaction to manage inflammatory cell recruitment
por: Marentette, John, et al.
Publicado: (2015)

Functional Consequences of Mutations and Polymorphisms in the Coding Region of the PAF Acetylhydrolase (PAF-AH) Gene
por: Stafforini, Diana M.
Publicado: (2009)

Pulmonary injury after intestinal ischemia and reperfusion injury: effects of treatment with lexipafant, a PAF antagonist
por: Börjesson, A, et al.
Publicado: (1998)

Leyes PAF fiscal, 2008.
Publicado: (2008)

PAF and Haematopoiesis. I. 5-Fluoro-Uracil Induces PAF Production in Haematopoietic Organs of Rats
por: Denizot, Y., et al.
Publicado: (1994)

Bleomycin-induced lung injury in the rat: effects of the platelet-activating factor (PAF) receptor antagonist BN 52021 and platelet depletion.
por: Evans, T W, et al.
Publicado: (1990)

Sonochemical Degradation Kinetics of Methyl Violet in Aqueous Solutions
por: Wang, Xi Kui, et al.
Publicado: (2003)

Degradation Mechanism of Micro-Nanobubble Technology for Organic Pollutants in Aqueous Solutions
por: Zhou, Youbin, et al.
Publicado: (2022)

Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation
por: Xie, Ying, et al.
Publicado: (2018)

PAF49: An RNA Polymerase I subunit essential for rDNA transcription and stabilization of PAF53
por: McNamar, Rachel, et al.
Publicado: (2023)

Ionizing radiation induced degradation of diuron in dilute aqueous solution
por: Kovács, Krisztina, et al.
Publicado: (2015)

Sonochemical processes for the degradation of antibiotics in aqueous solutions: A review
por: Liu, Pengyun, et al.
Publicado: (2021)

Impact of gamma-irradiation on the degradation and mineralization of hydroxychloroquine aqueous solutions
por: Zaouak, A., et al.
Publicado: (2022)

Fish polar lipids retard atherosclerosis in rabbits by down-regulating PAF biosynthesis and up-regulating PAF catabolism
por: Nasopoulou, Constantina, et al.
Publicado: (2011)

Platelet-Activating Factor (PAF) Antagonistic Activity of a New Biflavonoid from Garcinia nervosa var. pubescens King
por: Jalil, Juriyati, et al.
Publicado: (2012)

Synergistic Neuroprotection by a PAF Antagonist Plus a Docosanoid in Experimental Ischemic Stroke: Dose-Response and Therapeutic Window
por: Reid, Madigan M., et al.
Publicado: (2022)

ROBO4 deletion ameliorates PAF-mediated skin inflammation via regulating the mRNA translation efficiency of LPCAT1/LPCAT2 and the expression of PAF receptor
por: Xiao, Xiaoqiang, et al.
Publicado: (2020)

Degradation of formaldehyde aqueous solution by Bi based catalyst and its activity evaluation
por: Wang, Runquan, et al.
Publicado: (2022)

The Mechanism of Mycobacterium smegmatis PafA Self-Pupylation
por: Chen, Xuejie, et al.
Publicado: (2016)

Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimb
por: Dobbins, D. E.
Publicado: (1992)

Immobilization of laccase on chitosan functionalized halloysite nanotubes for degradation of Bisphenol A in aqueous solution: degradation mechanism and mineralization pathway
por: Wang, Zhaobo, et al.
Publicado: (2022)

Systematic Investigation of the Synergistic and Antagonistic Effects on the Removal of Pyrene and Copper onto Mesoporous Silica from Aqueous Solutions
por: Li, Haiyan, et al.
Publicado: (2019)

Effectiveness of Ultrasound and Ultraviolet Irradiation on Degradation of Carbaryl from Aqueous Solutions
por: Khoobdel, M, et al.
Publicado: (2010)

Degradation of 4-Chlorophenol in Aqueous Solution by Sono-Electro-Fenton Process
por: Nazari, Roya, et al.
Publicado: (2018)

The application of photoelectrocatalysis in the degradation of rhodamine B in aqueous solutions: a review
por: Yusuf, Tunde Lewis, et al.
Publicado: (2022)

Free radical induced degradation and computational studies of hydroxychloroquine in aqueous solution
por: Rath, Madhab C., et al.
Publicado: (2023)

Human PAF1 inhibition of HIV-1
por: Alonso, Ana Guerrero, et al.
Publicado: (2013)

Signalling mechanisms in PAF-induced intestinal failure
por: Lautenschläger, Ingmar, et al.
Publicado: (2017)

A PAF receptor antagonist inhibits acute airway inflammation and late-phase responses but not chronic airway inflammation and hyperresponsiveness in a primate model of asthma
por: Gundel, R. H., et al.
Publicado: (1992)

Degradation of the antibiotic ornidazole in aqueous solution by using nanoscale zero-valent iron particles: kinetics, mechanism, and degradation pathway
por: Zhang, Yanchang, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_kb2juaglrjnph02ddf96uov82v