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APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy
Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance. PD-L1/PD-1 checkpoint immunotherapy is a highly promising approach to overcome these protective sig...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350681/ https://www.ncbi.nlm.nih.gov/pubmed/30723579 http://dx.doi.org/10.1080/2162402X.2018.1550341 |