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Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer

Host responses to tumor cells include tumor suppressing or promoting mechanisms. We sought to detail the effect of Hedgehog (Hh) pathway inhibition on the composition of the mammary tumor immune portfolio. We hypothesized that Hh signaling mediates a crosstalk between breast cancer cells and macroph...

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Detalles Bibliográficos
Autores principales:	Hanna, Ann, Metge, Brandon J., Bailey, Sarah K., Chen, Dongquan, Chandrashekar, Darshan S., Varambally, Sooryanarayana, Samant, Rajeev S., Shevde, Lalita A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350695/ https://www.ncbi.nlm.nih.gov/pubmed/30723576 http://dx.doi.org/10.1080/2162402X.2018.1548241

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