Cargando…

Synthesising quantitative and qualitative evidence to inform guidelines on complex interventions: clarifying the purposes, designs and outlining some methods

Guideline developers are increasingly dealing with more difficult decisions concerning whether to recommend complex interventions in complex and highly variable health systems. There is greater recognition that both quantitative and qualitative evidence can be combined in a mixed-method synthesis an...

Descripción completa

Detalles Bibliográficos
Autores principales: Noyes, Jane, Booth, Andrew, Moore, Graham, Flemming, Kate, Tunçalp, Özge, Shakibazadeh, Elham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350750/
https://www.ncbi.nlm.nih.gov/pubmed/30775016
http://dx.doi.org/10.1136/bmjgh-2018-000893
_version_ 1783390498921119744
author Noyes, Jane
Booth, Andrew
Moore, Graham
Flemming, Kate
Tunçalp, Özge
Shakibazadeh, Elham
author_facet Noyes, Jane
Booth, Andrew
Moore, Graham
Flemming, Kate
Tunçalp, Özge
Shakibazadeh, Elham
author_sort Noyes, Jane
collection PubMed
description Guideline developers are increasingly dealing with more difficult decisions concerning whether to recommend complex interventions in complex and highly variable health systems. There is greater recognition that both quantitative and qualitative evidence can be combined in a mixed-method synthesis and that this can be helpful in understanding how complexity impacts on interventions in specific contexts. This paper aims to clarify the different purposes, review designs, questions, synthesis methods and opportunities to combine quantitative and qualitative evidence to explore the complexity of complex interventions and health systems. Three case studies of guidelines developed by WHO, which incorporated quantitative and qualitative evidence, are used to illustrate possible uses of mixed-method reviews and evidence. Additional examples of methods that can be used or may have potential for use in a guideline process are outlined. Consideration is given to the opportunities for potential integration of quantitative and qualitative evidence at different stages of the review and guideline process. Encouragement is given to guideline commissioners and developers and review authors to consider including quantitative and qualitative evidence. Recommendations are made concerning the future development of methods to better address questions in systematic reviews and guidelines that adopt a complexity perspective.
format Online
Article
Text
id pubmed-6350750
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-63507502019-02-15 Synthesising quantitative and qualitative evidence to inform guidelines on complex interventions: clarifying the purposes, designs and outlining some methods Noyes, Jane Booth, Andrew Moore, Graham Flemming, Kate Tunçalp, Özge Shakibazadeh, Elham BMJ Glob Health Analysis Guideline developers are increasingly dealing with more difficult decisions concerning whether to recommend complex interventions in complex and highly variable health systems. There is greater recognition that both quantitative and qualitative evidence can be combined in a mixed-method synthesis and that this can be helpful in understanding how complexity impacts on interventions in specific contexts. This paper aims to clarify the different purposes, review designs, questions, synthesis methods and opportunities to combine quantitative and qualitative evidence to explore the complexity of complex interventions and health systems. Three case studies of guidelines developed by WHO, which incorporated quantitative and qualitative evidence, are used to illustrate possible uses of mixed-method reviews and evidence. Additional examples of methods that can be used or may have potential for use in a guideline process are outlined. Consideration is given to the opportunities for potential integration of quantitative and qualitative evidence at different stages of the review and guideline process. Encouragement is given to guideline commissioners and developers and review authors to consider including quantitative and qualitative evidence. Recommendations are made concerning the future development of methods to better address questions in systematic reviews and guidelines that adopt a complexity perspective. BMJ Publishing Group 2019-01-25 /pmc/articles/PMC6350750/ /pubmed/30775016 http://dx.doi.org/10.1136/bmjgh-2018-000893 Text en © World Health Organization 2019. Licensee BMJ. https://creativecommons.org/licenses/by-nc/3.0/igo/This is an open access article distributed under the terms of the Creative Commons Attribution IGO License (CC BY NC 3.0 IGO (https://creativecommons.org/licenses/by-nc/3.0/igo/) ), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited. In any reproduction of this article there should not be any suggestion that WHO or this article endorse any specific organization or products. The use of the WHO logo is not permitted. This notice should be preserved along with the article’s original URL.Disclaimer: The author is a staff member of the World Health Organization. The author alone is responsible for the views expressed in this publication and they do not necessarily represent the views, decisions or policies of the World Health Organization.
spellingShingle Analysis
Noyes, Jane
Booth, Andrew
Moore, Graham
Flemming, Kate
Tunçalp, Özge
Shakibazadeh, Elham
Synthesising quantitative and qualitative evidence to inform guidelines on complex interventions: clarifying the purposes, designs and outlining some methods
title Synthesising quantitative and qualitative evidence to inform guidelines on complex interventions: clarifying the purposes, designs and outlining some methods
title_full Synthesising quantitative and qualitative evidence to inform guidelines on complex interventions: clarifying the purposes, designs and outlining some methods
title_fullStr Synthesising quantitative and qualitative evidence to inform guidelines on complex interventions: clarifying the purposes, designs and outlining some methods
title_full_unstemmed Synthesising quantitative and qualitative evidence to inform guidelines on complex interventions: clarifying the purposes, designs and outlining some methods
title_short Synthesising quantitative and qualitative evidence to inform guidelines on complex interventions: clarifying the purposes, designs and outlining some methods
title_sort synthesising quantitative and qualitative evidence to inform guidelines on complex interventions: clarifying the purposes, designs and outlining some methods
topic Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350750/
https://www.ncbi.nlm.nih.gov/pubmed/30775016
http://dx.doi.org/10.1136/bmjgh-2018-000893
work_keys_str_mv AT noyesjane synthesisingquantitativeandqualitativeevidencetoinformguidelinesoncomplexinterventionsclarifyingthepurposesdesignsandoutliningsomemethods
AT boothandrew synthesisingquantitativeandqualitativeevidencetoinformguidelinesoncomplexinterventionsclarifyingthepurposesdesignsandoutliningsomemethods
AT mooregraham synthesisingquantitativeandqualitativeevidencetoinformguidelinesoncomplexinterventionsclarifyingthepurposesdesignsandoutliningsomemethods
AT flemmingkate synthesisingquantitativeandqualitativeevidencetoinformguidelinesoncomplexinterventionsclarifyingthepurposesdesignsandoutliningsomemethods
AT tuncalpozge synthesisingquantitativeandqualitativeevidencetoinformguidelinesoncomplexinterventionsclarifyingthepurposesdesignsandoutliningsomemethods
AT shakibazadehelham synthesisingquantitativeandqualitativeevidencetoinformguidelinesoncomplexinterventionsclarifyingthepurposesdesignsandoutliningsomemethods