Cargando…

Cyclophosphamide-induced testicular toxicity ameliorate by American ginseng treatment: An experimental study

BACKGROUND: Cyclophosphamide (CP) is one of the most invasive chemotherapeutic agents, which used commonly despite of its wide spectrum toxicity. Clinical evidence showed toxic side effects of CP in multiple organ systems. OBJECTIVE: The objective of the present study was to evaluate the effects of...

Descripción completa

Detalles Bibliográficos
Autores principales: Hosseini, Akram, Zare, Samad, Borzouei, Zahra, Ghaderi Pakdel, Firouz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research and Clinical Center for Infertility 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350852/
https://www.ncbi.nlm.nih.gov/pubmed/30775687
_version_ 1783390506367057920
author Hosseini, Akram
Zare, Samad
Borzouei, Zahra
Ghaderi Pakdel, Firouz
author_facet Hosseini, Akram
Zare, Samad
Borzouei, Zahra
Ghaderi Pakdel, Firouz
author_sort Hosseini, Akram
collection PubMed
description BACKGROUND: Cyclophosphamide (CP) is one of the most invasive chemotherapeutic agents, which used commonly despite of its wide spectrum toxicity. Clinical evidence showed toxic side effects of CP in multiple organ systems. OBJECTIVE: The objective of the present study was to evaluate the effects of American ginseng on CP-induced testicular toxicity in rats. MATERIALS AND METHODS: Adult male Wistar rats (220±30 gr) were randomly divided into four groups (n=7 in each). Group 1 as control received normal saline by gavage, group 2 received CP (6.1 mg/kg/day, i.p.) for a period of 50 days. Group 3 received American ginseng (500 mg/kg/day) by gavage. Group 4 received American ginseng (500 mg/kg/day) 1h prior to the administration of CP in the equal dose of group 2. The animals scarified one day after the last treatment and the effects of American ginseng on the sperm vital parameters, testicular functions, biochemical factors, and structural malformations evaluated. RESULTS: Serum testosterone concentration was significantly decreased whereas the level of malondialdehyde and DNA damage were significantly increased in animals of CP group (p<0.01). Co-administration of American ginseng reversed these parameters and improved recovery in CP+ginseng group. In addition, seminiferous tubules of testis severely damaged in the CP group but ginseng improved histologic changes in CP+ginseng group. CONCLUSION: The findings confirmed the protective effects of American ginseng on toxicity induced by CP in the reproductive system of male rats.
format Online
Article
Text
id pubmed-6350852
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Research and Clinical Center for Infertility
record_format MEDLINE/PubMed
spelling pubmed-63508522019-02-15 Cyclophosphamide-induced testicular toxicity ameliorate by American ginseng treatment: An experimental study Hosseini, Akram Zare, Samad Borzouei, Zahra Ghaderi Pakdel, Firouz Int J Reprod Biomed Original Article BACKGROUND: Cyclophosphamide (CP) is one of the most invasive chemotherapeutic agents, which used commonly despite of its wide spectrum toxicity. Clinical evidence showed toxic side effects of CP in multiple organ systems. OBJECTIVE: The objective of the present study was to evaluate the effects of American ginseng on CP-induced testicular toxicity in rats. MATERIALS AND METHODS: Adult male Wistar rats (220±30 gr) were randomly divided into four groups (n=7 in each). Group 1 as control received normal saline by gavage, group 2 received CP (6.1 mg/kg/day, i.p.) for a period of 50 days. Group 3 received American ginseng (500 mg/kg/day) by gavage. Group 4 received American ginseng (500 mg/kg/day) 1h prior to the administration of CP in the equal dose of group 2. The animals scarified one day after the last treatment and the effects of American ginseng on the sperm vital parameters, testicular functions, biochemical factors, and structural malformations evaluated. RESULTS: Serum testosterone concentration was significantly decreased whereas the level of malondialdehyde and DNA damage were significantly increased in animals of CP group (p<0.01). Co-administration of American ginseng reversed these parameters and improved recovery in CP+ginseng group. In addition, seminiferous tubules of testis severely damaged in the CP group but ginseng improved histologic changes in CP+ginseng group. CONCLUSION: The findings confirmed the protective effects of American ginseng on toxicity induced by CP in the reproductive system of male rats. Research and Clinical Center for Infertility 2018-11 /pmc/articles/PMC6350852/ /pubmed/30775687 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hosseini, Akram
Zare, Samad
Borzouei, Zahra
Ghaderi Pakdel, Firouz
Cyclophosphamide-induced testicular toxicity ameliorate by American ginseng treatment: An experimental study
title Cyclophosphamide-induced testicular toxicity ameliorate by American ginseng treatment: An experimental study
title_full Cyclophosphamide-induced testicular toxicity ameliorate by American ginseng treatment: An experimental study
title_fullStr Cyclophosphamide-induced testicular toxicity ameliorate by American ginseng treatment: An experimental study
title_full_unstemmed Cyclophosphamide-induced testicular toxicity ameliorate by American ginseng treatment: An experimental study
title_short Cyclophosphamide-induced testicular toxicity ameliorate by American ginseng treatment: An experimental study
title_sort cyclophosphamide-induced testicular toxicity ameliorate by american ginseng treatment: an experimental study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350852/
https://www.ncbi.nlm.nih.gov/pubmed/30775687
work_keys_str_mv AT hosseiniakram cyclophosphamideinducedtesticulartoxicityamelioratebyamericanginsengtreatmentanexperimentalstudy
AT zaresamad cyclophosphamideinducedtesticulartoxicityamelioratebyamericanginsengtreatmentanexperimentalstudy
AT borzoueizahra cyclophosphamideinducedtesticulartoxicityamelioratebyamericanginsengtreatmentanexperimentalstudy
AT ghaderipakdelfirouz cyclophosphamideinducedtesticulartoxicityamelioratebyamericanginsengtreatmentanexperimentalstudy