FUT2 Secretor Status Is Not Associated With Oral Poliovirus Vaccine Immunogenicity in South Indian Infants

FUT2 determines whether histo-blood group antigens are secreted at mucosal surfaces. Secretor status influences susceptibility to enteric viruses, potentially including oral poliovirus vaccine (OPV). We performed a nested case–control study to determine the association between FUT2 genotype (single-...

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Autores principales: Parker, Edward P K, Whitfield, Helena, Baskar, Chudarkodi, Giri, Sidhartha, John, Jacob, Grassly, Nicholas C, Kang, Gagandeep, Praharaj, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350944/
https://www.ncbi.nlm.nih.gov/pubmed/30239830
http://dx.doi.org/10.1093/infdis/jiy553
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author Parker, Edward P K
Whitfield, Helena
Baskar, Chudarkodi
Giri, Sidhartha
John, Jacob
Grassly, Nicholas C
Kang, Gagandeep
Praharaj, Ira
author_facet Parker, Edward P K
Whitfield, Helena
Baskar, Chudarkodi
Giri, Sidhartha
John, Jacob
Grassly, Nicholas C
Kang, Gagandeep
Praharaj, Ira
author_sort Parker, Edward P K
collection PubMed
description FUT2 determines whether histo-blood group antigens are secreted at mucosal surfaces. Secretor status influences susceptibility to enteric viruses, potentially including oral poliovirus vaccine (OPV). We performed a nested case–control study to determine the association between FUT2 genotype (single-nucleotide polymorphisms G428A, C302T, and A385T) and seroconversion among Indian infants who received a single dose of monovalent type 3 OPV. Secretor prevalence was 75% (89 of 118) in infants who seroconverted and 80% (97 of 122) in infants who did not seroconvert (odds ratio, 0.79; 95% confidence interval, .43–1.45). Our findings suggest that FUT2 genotype is not a key determinant of variation in OPV immunogenicity.
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spelling pubmed-63509442019-02-05 FUT2 Secretor Status Is Not Associated With Oral Poliovirus Vaccine Immunogenicity in South Indian Infants Parker, Edward P K Whitfield, Helena Baskar, Chudarkodi Giri, Sidhartha John, Jacob Grassly, Nicholas C Kang, Gagandeep Praharaj, Ira J Infect Dis Major Articles and Brief Reports FUT2 determines whether histo-blood group antigens are secreted at mucosal surfaces. Secretor status influences susceptibility to enteric viruses, potentially including oral poliovirus vaccine (OPV). We performed a nested case–control study to determine the association between FUT2 genotype (single-nucleotide polymorphisms G428A, C302T, and A385T) and seroconversion among Indian infants who received a single dose of monovalent type 3 OPV. Secretor prevalence was 75% (89 of 118) in infants who seroconverted and 80% (97 of 122) in infants who did not seroconvert (odds ratio, 0.79; 95% confidence interval, .43–1.45). Our findings suggest that FUT2 genotype is not a key determinant of variation in OPV immunogenicity. Oxford University Press 2019-02-15 2018-09-19 /pmc/articles/PMC6350944/ /pubmed/30239830 http://dx.doi.org/10.1093/infdis/jiy553 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Parker, Edward P K
Whitfield, Helena
Baskar, Chudarkodi
Giri, Sidhartha
John, Jacob
Grassly, Nicholas C
Kang, Gagandeep
Praharaj, Ira
FUT2 Secretor Status Is Not Associated With Oral Poliovirus Vaccine Immunogenicity in South Indian Infants
title FUT2 Secretor Status Is Not Associated With Oral Poliovirus Vaccine Immunogenicity in South Indian Infants
title_full FUT2 Secretor Status Is Not Associated With Oral Poliovirus Vaccine Immunogenicity in South Indian Infants
title_fullStr FUT2 Secretor Status Is Not Associated With Oral Poliovirus Vaccine Immunogenicity in South Indian Infants
title_full_unstemmed FUT2 Secretor Status Is Not Associated With Oral Poliovirus Vaccine Immunogenicity in South Indian Infants
title_short FUT2 Secretor Status Is Not Associated With Oral Poliovirus Vaccine Immunogenicity in South Indian Infants
title_sort fut2 secretor status is not associated with oral poliovirus vaccine immunogenicity in south indian infants
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350944/
https://www.ncbi.nlm.nih.gov/pubmed/30239830
http://dx.doi.org/10.1093/infdis/jiy553
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