Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides

The development of antidotes to organophosphate poisons is an important aspect of modern pharmacology. Recombinant acetylcholinesterase and butyrylcholinesterase are effective DNA-encoded acceptors of organophosphate poisons and, in particular, pesticides. Here, we present the results of a study on...

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Detalles Bibliográficos
Autores principales: Palikov, V. A., Terekhov, S. S., Palikova, Yu. A., Khokhlova, O. N., Kazakov, V. A., Dyachenko, I. A., Panteleev, S. V., Mokrushina, Yu. A., Knorre, V. D., Shamborant, O. G., Smirnov, I. V., Gabibov, A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351027/
https://www.ncbi.nlm.nih.gov/pubmed/30713772
Descripción
Sumario:The development of antidotes to organophosphate poisons is an important aspect of modern pharmacology. Recombinant acetylcholinesterase and butyrylcholinesterase are effective DNA-encoded acceptors of organophosphate poisons and, in particular, pesticides. Here, we present the results of a study on the effectiveness of recombinant butyrylcholinesterase (BChE) in modeling organophosphate poisoning caused by oral administration of paraoxon at a dose of 2 mg / kg. The study showed a high activity of BChE as a protective agent for subchronic anticholinesterase poisoning in an in vivo model. The administration of BChE in a dose of 20 mg / kg allows one to avoid mortality, and also contributed to rapid recovery after model poisoning.

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